نتایج جستجو برای: exosome activity

تعداد نتایج: 1137073  

Journal: :RNA 2017
Sebastian Falk Jan-Niklas Tants Jerôme Basquin Matthias Thoms Ed Hurt Michael Sattler Elena Conti

The nuclear exosome and the associated RNA helicase Mtr4 participate in the processing of several ribonucleoprotein particles (RNP), including the maturation of the large ribosomal subunit (60S). S. cerevisiae Mtr4 interacts directly with Nop53, a ribosomal biogenesis factor present in late pre-60S particles containing precursors of the 5.8S rRNA. The Mtr4-Nop53 interaction plays a pivotal role...

Journal: :The Biochemical journal 2004
Karine Laulagnier Claude Motta Safouane Hamdi Sébastien Roy Florence Fauvelle Jean-François Pageaux Toshihide Kobayashi Jean-Pierre Salles Bertrand Perret Christian Bonnerot Michel Record

Exosomes are small vesicles secreted from multivesicular bodies, which are able to stimulate the immune system leading to tumour cell eradication. We have analysed lipids of exosomes secreted either upon stimulation from rat mast cells (RBL-2H3 cells), or constitutively from human dendritic cells. As compared with parent cells, exosomes displayed an enrichment in sphingomyelin, but not in chole...

Journal: :RNA 2012
Shakir Sayani Guillaume F Chanfreau

The nuclear exosome and the nonsense-mediated mRNA decay (NMD) pathways have been implicated in the degradation of distinct unspliced transcripts in Saccharomyces cerevisiae. In this study we show that these two systems can act sequentially on specific unspliced pre-mRNAs to limit their accumulation. Using steady-state and decay analyses, we show that while specific unspliced transcripts rely m...

2007
Ruth Canavan Ursula Bond

The nuclear exosome, a macromolecular complex of 3' to 5' exonucleases, is required for the post-transcriptional processing of a variety of RNAs including rRNAs and snoRNAs. Additionally, this complex forms part of a nuclear surveillance network where it acts to degrade any aberrantly processed mRNAs in the nucleus. The exosome complex has been implicated in the biogenesis pathway of general me...

2016
Jennifer K Lang Rebeccah F Young Hashmat Ashraf John M Canty

Numerous studies have shown a beneficial effect of cardiosphere-derived cell (CDC) therapy on regeneration of injured myocardium. Paracrine signaling by CDC secreted exosomes may contribute to improved cardiac function. However, it has not yet been demonstrated by a genetic approach that exosome release contributes to the therapeutic effect of transplanted CDCs. By employing a lentiviral knockd...

2010
Sophia Hartung Theresa Niederberger Marianne Hartung Achim Tresch Karl-Peter Hopfner

RNA exosomes are large multisubunit assemblies involved in controlled RNA processing. The archaeal exosome possesses a heterohexameric processing chamber with three RNase-PH-like active sites, capped by Rrp4- or Csl4-type subunits containing RNA-binding domains. RNA degradation by RNA exosomes has not been studied in a quantitative manner because of the complex kinetics involved, and exosome fe...

Journal: :Journal of Experimental & Clinical Cancer Research 2021

Abstract Background Exosomes are membrane-bound extracellular vesicles of 40–150 nm in size, that produced by many cell types, and play an important role the maintenance cellular homeostasis. Exosome secretion allows for selective removal harmful substances from cells. However, it remains unclear whether this process also takes place glioma Methods Herein, tumour-suppressor miR-375 was explored...

Journal: :Biochemical and biophysical research communications 2014
Worrawalan Phoonsawat Ayako Aoki-Yoshida Takeshi Tsuruta Kei Sonoyama

Exosomes are membrane vesicles 30-120 nm in diameter that are released by many cell types and carry a cargo of proteins, lipids, mRNA, and microRNA. Cultured adipocytes reportedly release exosomes that may play a role in cell-to-cell communication during the development of metabolic diseases. However, the characteristics and function of exosomes released from adipocytes in vivo remain to be elu...

2001
Nobuhiro Suzuki Eishi Noguchi Nobutaka Nakashima Masaya Oki Tomoyuki Ohba Alan Tartakoff Masamichi Ohishi Takeharu Nishimoto

Dis3p, a subunit of the exosome, interacts directly with Ran. To clarify the relationship between the exosome and the RanGTPase cycle, a series of temperature-sensitive Saccharomyces cerevisiae dis3 mutants were isolated and their 5.8S rRNA processing was compared with processing in strains with mutations in a S. cerevisiae Ran homologue, Gsp1p. In both dis3 and gsp1 mutants, 39 processing of 7...

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