BACKGROUND In multiple sclerosis (MS), the epsilon4 allele of apolipoprotein E (APOE epsilon4) has been associated with more rapid clinical worsening and more severe tissue damage on magnetic resonance imaging. OBJECTIVE To use proton magnetic resonance spectroscopy ((1)H-MRS) to further explore the biochemical changes in the brains of patients with MS associated with APOE epsilon4. DESIGN ...

BACKGROUND No clinical test is currently available and validated to measure the maximum walking speed (WS) of multiple sclerosis (MS) patients. Since the Timed 25-Foot Walk Test (T25FW) is performed with a static start, it takes a significant proportion of the distance for MS patients to reach their maximum pace. OBJECTIVES In order to capture the maximum WS and to quantify the relative impac...

OBJECTIVES In multiple sclerosis (MS), several neuroimmunomodulatory effectors are known, including melatonin. They are able to influence disease-related neurophysiogical changes (disability or impaired vision) as well as neuropsychological performance (e.g. cognition and depression). In this study we assessed the relationship between immunomodulation on psycho-neuroimmunological functions in b...

Depression and anxiety are reported to be prevalent in patients with MS, with prevalence rates ranging from 20% to 50%. Unfortunately, the rates, patterns, and risk factors are not well studied in our Middle East region, and, to our knowledge, not at all in UAE. Using standardized screening tools, we observed that 17% and 20% of 80 patients seen in MS clinic had scores consistent with major dep...

Yes, many clinical neurologists, myself included, have, on discussing the implications of multiple sclerosis with a newly diagnosed patient, emphasized the possibility of the illness being mild and have quoted figures of about 20% prevalence of benign MS after 15 or more years of illness. Remember that 20 years ago we had no treatments to offer the person with MS and compassion meant offering s...

OBJECTIVES To develop a model of disease progression using multiple sclerosis (MS) as an exemplar. STUDY DESIGN AND SETTINGS Two observational cohorts, the University of Wales MS (UoWMS), UK (1976), and British Columbia MS (BCMS) database, Canada (1980), with longitudinal disability data [the Expanded Disability Status Scale (EDSS)] were used; individuals potentially eligible for MS disease-m...

The spinal cord is one of the two main targets neuromyelitis optica (NMO). aim this study was to highlight cervical atrophy in NMO patients as compared controls and assess correlations between clinical characteristics MRI data. This prospective investigated 15 with a diagnosis NMOSD healthy controls. whole explored by MRI. cross-sectional area (CSA) estimate at every level cup. measurement then...

Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases in adults that cause disability in patients. Different studies were conducted on more rapid diagnosis of the disease such as measuring serum or cerebrospinal fluid (CSF) contents. Objectives: The current study aimed at measuring amyloid β (Aβ) serum levels in patients with relapsing-remitting MS. Mater...

BACKGROUND Sleep disturbances in multiple sclerosis (MS) have received little research attention despite the potential influence it may have on the impact of the disease. The aim of this study was to evaluate the prevalence of sleep disturbances in a Lithuanian community sample of individuals with the relapsing remitting multiple sclerosis (RRMS) and its relation with depression, anxiety, and h...