OBJECTIVE To evaluate balance control with Balance Rehabilitation Unit (BRU™) posturography in patients with multiple sclerosis (MS). METHOD A cross controlled study was performed including 39 relapsing-remitting multiple sclerosis patients with scores less than or equal to 4 in the Expanded Disability Status Scale (EDSS), and a homogeneous control group consisting of 65 healthy individuals, ...

The present study aimed at evaluating respiratory parameters in multiple sclerosis (MS). The sample comprised 30 patients with MS diagnosis and 30 healthy subjects, matched by gender and age. Neurological assessment, expanded disability status scale (EDSS), manovacuometry, and peak flow (PEF) were performed. Patients with MS had lower values of maximum inspiratory (MIP) and expiratory (MEP) pre...

BackgroundLow vitamin D levels, tobacco use and high body mass index (BMI) have been linked to adverse disease outcomes in multiple sclerosis (MS), but their influence on long-term disability progression remains unclear. Therefore, we explored whether these modifiable lifestyle factors were associated with 10-year clinical patients MS.MethodsIn this prospective study, a cohort of 88 relapsing-r...

background: multiple sclerosis (ms) is an inflammatory and demyelinating disease of central nervous system (cns). the aim of the present study was to determine the type and the frequency of initial presenting symptoms in patients with ms and their relation with demographic characteristics in babol, northern iran. methods: all patients of this study were recruited over a ten year period from 200...

BACKGROUND In neuromyelitis optica (NMO), one of the underlying pathogenic mechanisms is the formation of antigen-antibody complexes which can trigger an inflammatory response by inducing the infiltration of neutrophils in lesions. Epithelial neutrophil-activating peptide 78 (ENA 78), known as Chemokine (C-X-C motif) ligand 5 (CXCL5), belongs to the ELR-CXCL family. It recruits and activates ne...

We have tested the hypothesis that restless leg syndrome (RLS) is related to quality of sleep, fatigue and clinical disability in multiple sclerosis (MS). The diagnosis of RLS used the four minimum criteria defined by the International Restless Legs Syndrome Study Group. Fatigue was assessed by the Fatigue Severity Scale (FSS >27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6...

BACKGROUND Multiple sclerosis (MS) is a chronic progressive condition affecting the central nervous system. Progression of MS results in increased level of disability and most patients will eventually experience some degree of functional impairment and impaired mobility. Costs and burdens escalate as MS disability increases. However, there is a lack of recent data on the impact of MS disability...

Background Multiple sclerosis (MS) is characterized by a great inter-individual variability in disease course and severity. Some patients experience a rather mild course, controversially called 'benign MS' (BMS). The usefulness of this entity in clinical practice remains unclear. Methods We performed a literature search in PubMed, Web of Science and Cochrane Library databases from November 19...

Subtyping relapsing–remitting multiple sclerosis (RRMS) patients may help predict disease progression and triage for treatment. We aimed to subtype RRMS by structural MRI investigate their clinical significances. 155 relapse-remitting MS 210 healthy controls (HC) were retrospectively enrolled with 3DT1, diffusion tensor imaging (DTI) resting-state functional MRI. Z scores of cortical deep gray ...