The World Health Organization estimates human mortality from endemic canine rabies to be 55,000 deaths/year. Limited supply hampers the accessibility of appropriate lifesaving treatment, particularly in areas where rabies is endemic. Anti-rabies antibodies are key to protection against lethal rabies. Currently, only human and equine polyclonal anti-rabies immune globulin (HRIG and ERIG) is avai...

In China, rabies is a significant public health concern where dogs remain the main reservoir of disease transmission to humans; rabies-related mortality ranks second in the world.We compiled all published articles and official documents on rabies in mainland China to examine challenges and needs to eliminate rabies in the country. The Chinese authorities have identified rabies as a priority, re...

Rabies a zoonotic disease prevalent worldwide, with high mortality, more than a third of global toll in India. Dogs are the common animals involved. In Americas, bat bites are the most common source of rabies infection in humans. Rabies is caused by lyssaviruses including rabies virus and Australian bat lyssavirus. Disease produces almost fatal encephalitis in humans and in other mammals. From ...

Rabies is a lethal form of encephalitis and enzootic in many parts of Asia and Africa where it poses a significant veterinary and public health concern [1,2]. Rabies is caused by neurotropic viruses of the genus Lyssavirus. It is a zoonotic infection mainly transmitted through the saliva of infected animal. Extensive efforts in developed countries (America and Europe) have largely controlled do...

Rabies is a neglected zoonotic disease that is preventable in humans by appropriate post-exposure prophylaxis (PEP). However, current PEP relies on polyclonal immune globulin products purified from pooled human (HRIG) or equine (ERIG) plasma that are either in chronic shortage or in association with safety concerns. Here, we present the development of an antibody cocktail, SYN023, made of two n...

Rabies is a neglected tropical disease associated with almost universal mortality. It is most often caused by the rabies virus (RABV) and transmitted to humans through the bite of dogs, so-called ‘canine’ rabies. Approximately half of the considerable global burden of disease occurs in Asia where its burden falls most heavily on poor, rural populations with a disproportionate impact on children...

BACKGROUND Rabies is preventable by pre- and/or post-exposure prophylaxis consisting of series of rabies vaccinations and in some cases the use of immunoglobulins. The success of vaccination can be estimated either by measuring virus neutralising antibodies or by challenge experiment. Vaccines based on rabies virus offer cross-protection against other lyssaviruses closely related to rabies viru...

Rabies post exposure prophylaxis (PEP) includes administration of both vaccine and anti-rabies immunoglobulin. Rabies immunoglobulins are expensive and available in limited quantities. There is an inherent variability in quality and specificity between batches of immunoglobulin preparations and possibility of contamination with known or unknown pathogens. To provide a cost-effective and safe re...

BACKGROUND In Mozambique, the majority of rabies outbreaks are unreported and data on the epidemiological features of human rabies and animal bites are scarce. An outbreak of human rabies in adjacent Maputo and Matola cities in 2014 prompted us to investigate the epidemiology, clinical features and risk factors of human rabies and animal bites in the two cities. METHODOLOGY/PRINCIPAL FINDINGS...

Taiwan had been free of indigenous human and animal rabies case since canine rabies was eliminated in 1961. In July 2013, rabies was confirmed among three wild ferret-badgers, prompting public health response to prevent human rabies cases. This descriptive study reports the immediate response to the reemergence of rabies in Taiwan. Response included enhanced surveillance for human rabies cases ...