In this study, high-conductance Ca2+-activated K+ channels from rat skeletal muscle were incorporated into planar phospholipid bilayers, and discrete blockade of single channels by Ba2+ was studied. With 150 mM K+ held constant in the internal solution, increasing external K+ over the range 100-1,000 mM raises the rate of Ba2+ dissociation. This "enhancement effect," which operates at K+ concen...

voltage stability may be improved by various control functions. in this paper, it is shown that how high side voltage control (hivc) may be employed for this purpose. two test systems, namely a 22- bus and ieee u8-bus systems are used to demonstrate the proposed tuning strategy for hsvc control parameters.

A protocol employing weak values (WVs) to obtain ultrasensitive amplification of weak signals in the context of a solid-state setup is proposed. We consider an Aharonov-Bohm interferometer where both the orbital and the spin degrees of freedom are weakly affected by the presence of an external charge to be detected. The interplay between the spin and the orbital WVs leads to a significant ampli...

The effects of phosphorylation on the properties of the 20-pS channel of the squid giant axon were studied using the cut-open axon technique. Phosphorylation of the channel was achieved by photoreleasing caged ATP (inside the patch pipette) in the presence of the catalytic subunit of the protein kinase A. An inverted K+ gradient (500 K+ external parallel 5 K+ internal) was used to study the act...

Inactivation of currents carried by Ba2+ and Ca2+, as well as intramembrane charge movement from L-type Ca2+ channels were studied in guinea pig ventricular myocytes using the whole-cell patch clamp technique. Prolonged (2 s) conditioning depolarization caused substantial reduction of charge movement between -70 and 10 mV (charge 1, or charge from noninactivated channels). In parallel, the char...

This paper proposes a simple, yet effective and affordable, manufacturing process to enhance the overall efficiency of voltage generation by a triboelectric generator (TEG) using 3D printers for energy-harvesting applications. The proposed method can be classified as macroscale surface patterning, in contrast to microand nanoscale patterning of TEG proposed in previous studies. Experiments were...

A potential role for sialic acid in the voltage-dependent gating of rat skeletal muscle sodium channels (rSkM1) was investigated using Chinese hamster ovary (CHO) cells stably transfected with rSkM1. Changes in the voltage dependence of channel gating were observed after enzymatic (neuraminidase) removal of sialic acid from cells expressing rSkM1 and through the expression of rSkM1 in a sialyla...

Effects of Pb and several other metal ions on various distinct types of voltage-, receptor- and Ca-activated ion channels have been investigated in cultured N1E-115 mouse neuroblastoma cells. Experiments were performed using the whole-cell voltage clamp and single-channel patch clamp techniques. External superfusion of nanomolar to submillimolar concentrations of Pb causes multiple effects on i...

the microbial fuel cells (mfcs) are a kind of systems through which the anaerobic bacteriaalong with the oxidation of simple or complicated organic matter in the wastewater can generate the electricpower. this is a modern approach used in generation of the clean and renewable energy. in this research, two pilot laboratories of double-chamber microbial fuel cells were made. one of them contained...