Purpose. Primary extra-osseous osteosarcomas are uncommon lesions, and those originating within the lung are especially rare, with few case reports existing in the literature.Patient. We report the case of a 48-year-old male smoker with a primary osteosarcoma of the right lower lung lobe.Results. Diagnosis was based on histopathological findings of a poorly differentiated sarcoma with malignant...

A novel mathematical model to simulate stem cells differentiation into specialized cells of connective or non-connective tissues is discussed. The model is based upon material balances for extra cellular matrix compounds, growth factors and nutrients coupled with a mass-structured population balance describing cell growth, proliferation and differentiation. The model is written in a general for...

In recent years it has become apparent that the hemostatic system has a role to play in regulating angiogenesis. This is achieved by components of the coagulation and fibrinolytic systems regulating proteolysis in the milieu and context of extra cellular matrix and the fibrin clot. It is also an emerging paradigm that cryptic fragments, released by proteolysis from components of the coagulation...

We describe a model of cytoskeletal mechanics based on the force-induced conformational change of protein cross-links in a stressed polymer network. Slow deformation of simulated networks containing cross-links that undergo repeated, serial domain unfolding leads to an unusual state-with many cross-links accumulating near the critical force for further unfolding. This state is robust to thermal...

In extensive burns it becomes difficult for fibroblasts to migrate from the periphery of the healthy tissue and colonize the injured area. Even under such circumstances healing takes place, and this is attributed to the differentiation of circulating fibrocytes which enter the wound site. This normal cell type is identified in keloid fibroblasts: it expresses fibrocyte markers and secretes extr...

Tumors are unorganized organs that contain many different cell types that communicate with cancer cells (Kalluri NRC 2006). The central goal of our laboratory is to evaluate the role of these non-cancer cells in cancer progression and metastasis. Cancer progression significantly depends on the influence of many different host cells. Whether such host responses are recruited to control cancer pr...

Matrix metalloproteinases are an integral component of the organ-specific tissue microenvironment, primarily participating in regulation state integrative-buffer metabolic environment, remodeling, morphogenesis and immunogenesis, genesis pathological vascular diseases. Therefore, issues related to matrix metalloproteinase activity under altered gravity a matter high urgency for space biomedicin...

Tissue engineering has recommended the development of biomaterials for implantable porous scaffolds at the injured site, which temporarily acted as the supporting materials for ingrowths of the cells and degraded along with extra cellular matrix production, vascularization and tissue regeneration. Usually, three dimensional scaffolds play the most important role in the design of Tissue Engineer...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: to measure the amounts of fluoride released from fluoride-containing materials, four glass ionomer cements (fuji ix, fuji vii, fuji ix extra and fuji ii lc), a compomer (dyract extra) and a giomer (beautifil) were used in this study . methods: twenty cylindrical specimens were prepared from each material. the a...