The solubility behaviour of drug is one of the most challenging aspects in formulation development. Thus a greater understanding of dissolution and absorption behaviour of drug with low aqueous solubility is required to successfully formulate them into more soluble and hence bioavailable drug product. Therefore different approaches are being explored to enhance the solubility of poorly water so...

A 28-year-old female presented to the Emergency Department (ED) with a chief complaint of strings protruding from her vagina. The patient also complained of recurrent symptoms of cystitis and occasional hematuria over the past five months without resolution after treatment. The patient underwent ED evaluation and was noted to have strings coated in calculus protruding from her urethral meatus. ...

Multidrug resistance efflux transporters threaten to reverse the progress treating infectious disease by extruding a wide range of drug and other cytotoxic compounds. One such drug transporter, EmrE, from the small multidrug resistance family, utilizes proton gradients as an energy source to drive substrate translocation. In an effort to understand the molecular structural basis of this transpo...

Huntington's disease (HD) is classically characterized as a movement disorder, however cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and bioinformatic data linking the Huntingtin protein (Htt) and KCC2, which is required for hyperpolarizing GABAergic inhibition, and the important role of inhibition in learning and memory, we hypothesized that aberrant KCC2 functi...

Prism elements arise in some printed circuit board modeling contexts, such as visualization and electromagnetic field modeling. Here we consider prisms built by extruding from triangular bases which result from constrained 2d Delaunay triangulation. The goal is to partition each extruded prism into sub-prisms of high quality that fit within the given printed circuit board layers. A prism qualit...

Calcium movement across plasma membranes occurs mainly by three routes: voltage-dependent calcium channels, adenosine 5'-triphosphate-driven calcium pump, and Na+-Ca2 exchange. The regulation of the intracellular ionized calcium is the consequence of two parallel calcium transport mechanisms: a high affinity, low capacity system responsible for extruding calcium during resting conditions (calci...

This paper describes novel algorithms that use absolute camera pose information to identify correspondence among point features in hundreds or thousands of images. Our incidence counting algorithm is a geometric approach to matching; it matches features by extruding them into an absolute 3-D coordinate system, then searching 3-D space for regions into which many features project. The absolute p...

Efflux mediated multidrug resistance (MDR) is a major problem in the treatment of bacterial, fungal and protozoal infections in addition to cancer chemotherapy. Among other well known mechanisms, efflux pumps are significant contributors to chemo-resistance. Efflux mediated resistance generally occurs through up-regulation of genes responsible for the expression of transporter proteins extrudin...

Several designs of a manufacturing line for the production of extruded foods were developed and compared with the current production line design. The manufacturing line consisted of six unit operations: batching, grinding, extruding, drying, further processing, and packing. The authors performed the comparisons by simulating the current design and the proposed alternatives. The alternatives con...

A boy, aged 10.5 years, with a Class II molar relationship and a very deep overbite, complaining of a gummy smile and anterior crowding, was treated nonextraction with a mini-implant and Twin-block and edgewise fixed appliances. Severely extruded and retroclined maxillary incisors were intruded and proclined with a nickel-titanium closed-coil spring anchored to a mini-implant and segmented wire...