Rheumatoid arthritis is a chronic inflammatory autoimmune disease whose etiology is still unknown. Extra-articular manifestations are not uncommon. F-18 fluoro-2-deoxyglucose (F-18 FDG) positron emission tomography combined with computed tomography (PET/CT) is a useful tool to assess neoplastic diseases. However, some inflammatory conditions may also show high F-18 FDG uptake. We report a sympt...

PURPOSE The purpose of this study is to give an overview of studies investigating the role of fludeoxyglucose F18 ((18)F-FDG) positron emission tomography (PET) scanning in patients with aortic aneurysms with a focus on molecular characteristics of the aneurysm wall. METHODS MEDLINE, EMBASE, and the Cochrane database were searched for relevant articles. After inclusion and exclusion, we selec...

BACKGROUND This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of (18)F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). RESULTS Tumor-bearing mice (squamous cell carcinoma) maintained at 37 degrees C were studied while breathing either normal air or carbogen (95% O(2), 5% CO2), k...

UNLABELLED Our objective was to evaluate (18)F-FDG PET uptake in patients with nonmetastatic and metastatic chromaffin-derived tumors. METHODS Twenty-eight consecutive unrelated patients with chromaffin tumors, including 9 patients with genetically determined disease, were studied. A combination of preoperative imaging work-up, surgical findings, and pathologic analyses was used to classify t...

OBJECTIVES Clinical tumor imaging with (18)F-FDG in PET is growing in demand. This article will provide a review of current patient preparation and imaging techniques. The goal is to make the PET study as noninvasive as possible for the patient while obtaining quality images. Communication and coordination when scheduling these studies involves the patient and radiopharmacy, scanner, and suppor...

UNLABELLED Brain imaging with glucose ((18)F-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority of one method have not been undertaken. METHODS Subjects with Alzheimer disease (AD; n = 38) and dementia with Lewy bodies (DLB; n = 30) and controls (n = 30) underwent (...

UNLABELLED The purpose of this study was to estimate the fetal radiation exposure resulting from (18)F-FDG PET procedures performed in pregnant patients with malignancies. METHODS Five pregnant patients with a biopsy-proven diagnosis of malignancy who underwent (18)F-FDG PET studies were retrospectively reviewed. All patients underwent PET-only studies (and not PET/CT studies) with a reduced ...

Fever of unknown origin (FUO) was originally defined as recurrent fever of 38.3 degrees C or higher, lasting 2-3 wk or longer, and undiagnosed after 1 wk of hospital evaluation. The last criterion has undergone modification and is now generally interpreted as no diagnosis after appropriate inpatient or outpatient evaluation. The 3 major categories that account for most FUOs are infections, mali...

Ocular sebaceous adenocarcinoma is a rare malignant tumor. We report an unusual case of orbital sebaceous adenocarcinoma in a 48-year-old woman. The patient underwent F-18 2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) to determine the initial clinical stage. (18)F-FDG-PET/CT showed strong uptake in the orbital lesion, but neither regional lymphatic...

The diagnosis of prosthetic valve endocarditis continues to present a diagnostic challenge, due to the lower sensitivity of the modified Duke criteria and a higher percentage of negative or inconclusive echocardiography results. Diagnostic delay might result in significant morbidity/mortality. Imaging modalities like 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/comput...