Embryonic exposure to the endocrine disruptor vinclozolin at the time of gonadal sex determination was previously found to promote transgenerational disease states. The actions of vinclozolin appear to be due to epigenetic alterations in the male germline that are transmitted to subsequent generations. Analysis of the transgenerational epigenetic effects on the male germline (i.e. sperm) identi...

Gestational infection is increasingly being recognized for its involvement as causative mechanism in severe developmental brain abnormalities and its contribution to the pathogenesis of psychopathologies later in life. First observations in the widely accepted maternal immune activation (MIA) model based upon the systemic administration of the viral mimetic Polyinosinic:polycytidylic acid (poly...

investigation of inheritance, mode of gene action and determination of effective breeding strategy for improvement of physiological and morpho-physiological traits specifically in drought stress conditions is very important. to determine the inheritance pattern and genetic parameters of quantitative characters in bread wheat (triticum aestivum), p1, p2, bc1, bc2, f1, f2 generations derived from...

due to cereal are affected by drought stress in their lifetime. in order to study gene action of bread wheat under drought stress condition, a generation mean analysis was performed using f1, f2 and f3 generations derived from roushan and kavir. generation mean analysis was performed based on joint scaling test. genetic parameters including additive effect (d), dominance effect (h), additive×ad...

Embryonic exposure to the endocrine disruptor vinclozolin at the time of gonadal sex determination was previously found to promote transgenerational disease states. The actions of vinclozolin appear to be due to epigenetic alterations in the male germline that are transmitted to subsequent generations. Analysis of the transgenerational epigenetic effects on the male germline (i.e. sperm) identi...

BACKGROUND Venous thromboembolism (VTE) is a common disease where known genetic risk factors explain only a small portion of the genetic variance. Then, the analysis of intermediate phenotypes, such as thrombin generation assay, can be used to identify novel genetic risk factors that contribute to VTE. OBJECTIVES To investigate the genetic basis of distinct quantitative phenotypes of thrombin...

Methods Potential founder fish with spinal curvatures were outcrossed with a wild type zebrafish line (AB) and the resulting siblings (F1 generation) crossed and the offspring (F2 generation) examined for signs of spinal curvature beginning at 14 days post fertilization (dpf). Spinal curvatures of the affected fish were visualized using either a Faxitron or by Alizarian red staining of the skel...

Bisphenol S is an endocrine disruptor exhibiting metabolic disturbances, especially following perinatal exposures. To date, no data are available on the obesogen effects of BPS in a mutligenerational issue. We investigated multigenerational study by focusing body weight, adipose tissue and plasma parameters male female mice. Pregnant C57BL6/J mice were exposed to (1.5 ?g/kg bw/day ie human equi...

BACKGROUND By altering specific developmental signaling pathways that are necessary for fetal lung development, perinatal nicotine exposure affects lung growth and differentiation, resulting in the offsprings' predisposition to childhood asthma; peroxisome proliferator-activated receptor gamma (PPARγ) agonists can inhibit this effect. However, whether the perinatal nicotine-induced asthma risk ...