Background Spondyloarthropathies (SpA) are chronic inflammatory arthritis, characterized by both peripheral and axial skeletal involvement some typical extra-articular marks; they tend to associate with several comorbidities can increase the risk of an impaired quality life (QoL). Already published data show SpA expression differs based on gender; in particular, women at higher a more pronounce...

Abstract Background Patients with Crohn’s disease (CD) experience reduced quality of life (QoL), and disease-related impact on work productivity, contributing to a high burden. This study evaluated the association achieving endoscopic outcomes at week 12 associated QoL 52 in patients CD treated upadacitinib (UPA). Methods post-hoc analysis data from two Phase 3 UPA induction (U-EXCEED U-EXCEL) ...

BACKGROUND It is estimated that 29% of deaths in Australia are caused by malignant disease each year and can be expected to increase with population ageing. In advanced cancer, the prevalence of fatigue is high at 70-90%, and can be related to the disease and/or the treatment. The negative impact of fatigue on function (physical, mental, social and spiritual) and quality of life is substantial ...

The few literature references suggesting adverse effects of high doses of ascorbic acid are outnumbered by a large number of clinical studies in which no adverse effects have been observed. Up to 5 g ascorbic acid daily may be administered safely even over a long term. Favourable effects of even higher doses in man may justify therapeutic trials in the range of 15 g daily which in our trials ha...

The Index Thomisticus Treebank is the largest available treebank for Latin; it contains Medieval Latin texts by Thomas Aquinas. After experimenting on its data with a number of dependency parsers based on different supervised machine learning techniques, we found that DeSR with a multilayer perceptron algorithm, a right-to-left transition, and a tailor-made feature model is the parser providing...

BACKGROUND & AIMS The new pan-genotypic regimen [sofosbuvir (SOF) and velpatasvir (VEL)] for hepatitis C virus (HCV) has been associated with high efficacy. The aim of this study was to assess patient-reported outcomes (PROs) of this regimen. METHODS The PRO data (CLDQ-HCV, SF-36, FACIT-F, WPAI) came from the ASTRAL-1 study, a multicenter multinational blinded placebo-controlled phase 3 clini...

Abstract Background Abdominal pain (AP), bowel urgency (BU), and fatigue are debilitating symptoms that reduce quality of life in patients with active ulcerative colitis (UC). Results from two Phase 3 induction trials (U-ACHIEVE [NCT02819635] U-ACCOMPLISH [NCT03653026]) showed significant improvements AP, BU, following upadacitinib (UPA) UC who had previously failed conventional or biologic the...

Background Psoriatic arthritis (PsA) can cause an impairment of patients’ quality life. Fatigue is a common and often underestimated symptom in PsA. Objectives We aimed to assess the characteristics fatigue Methods This was cross-sectional study including patients with PsA meeting CASPAR criteria. Socio-demographic, clinical biological data were collected. The FACIT score (Functional Assessment...

BACKGROUND The Spiritual Distress Assessment Tool (SDAT) is a 5-item instrument developed to assess unmet spiritual needs in hospitalized elderly patients and to determine the presence of spiritual distress. The objective of this study was to investigate the SDAT psychometric properties. METHODS This cross-sectional study was performed in a Geriatric Rehabilitation Unit. Patients (N = 203), a...