نتایج جستجو برای: factor 5

تعداد نتایج: 1954449  

Journal: :Acta crystallographica. Section F, Structural biology and crystallization communications 2005
Thomas D Mueller Maike Gottermeier Walter Sebald Joachim Nickel

Growth and differentiation factor 5 (GDF-5) belongs to the large TGF-beta superfamily of secreted signalling proteins and plays a pivotal role in skeletal development during embryogenesis. The gene for human GDF-5 was cloned, expressed in Escherichia coli and purified to homogeneity. Crystals were obtained that diffracted to 2.2 A resolution. A native data set was acquired, showing that the cry...

Journal: :Journal of virology 2009
Emma Poole Ian Groves Andrew MacDonald Yin Pang Antonio Alcami John Sinclair

Human cytomegalovirus (HCMV) regulates NF-kappaB during infection by a variety of mechanisms. For example, the HCMV gene product, UL144, is known to activate NF-kappaB in a tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-dependent manner, causing the upregulation of the chemokine CCL22 (MDC). Viral UL144 is expressed from the UL/b' region of the HCMV genome at early times post...

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