This report describes a murine amniotic fluid (MAF) immunosuppressive factor that has properties similar to transforming growth factor beta (TGF-beta). The MAF factor exhibits TGF-beta-like activity in stimulating soft agar colony formation by AKR-2B cells and inhibiting thymidine uptake by Mv1Lu cells. We demonstrate that both the immunosuppressive and TGF-beta-like activities of the MAF facto...

background: maturity-onset diabetes of the young (mody) is a heterogeneous entity of monogenic disorders characterized by autosomal dominant inheritance. eleven genes were related, including hnf4α, gck, hnf1α, ipf1, and hnf-1β, and various mutations are being reported. methods: to help the overall understanding of mody-related pathologic mutations, we studied a large mody family found in 2012, ...

We investigated the effect of transforming factor factor-beta(1) (TGF-beta(1)) on thromboxane B(2) (TXB(2)) and prostaglandin E(2) (PGE(2)) production in in vitro silica dust-exposed rat alveolar macrophages (AM). In the presence of 5 mug of anti-TGF-beta(1) antibodies, TXB(2) production decreased, but PGE(2) production increased. Addition of 2 ng of TGF-beta(1) to the culture medium potentiate...

Alteration in the expression of growth factors is widely accepted as being one of several critical defects in the generation of the malignant cell. In the present study, 19 human metastatic melanoma cell lines were compared to 14 normal human foreskin melanocyte cell lines for the production of RNA transcripts specific for 11 different growth factors. Using the extremely sensitive technique of ...