Background: Heart failure (HF) has become one of the most prevalent cardiovascular problems worldwide. Considering the beneficial effects of probiotics on human health, we aimed to investigate the anti-inflammatory effect of oral administration of Lactobacillus paracasei in HF induced by isoproterenol. Methods: Forty Wistar male rats weighing 80g on average were randomly assigned to five grou...

Annually more than 300 million patients (about 5% of the world population) undergo major surgery worldwide. Nearly 85% operations are noncardiac surgical procedures. Proper preoperative evaluation is important to reduce cardiovascular morbidity and mortality in undergoing surgery. Cardiac risk determined by two main factors: patient-related risk. Timing (Immediate, Urgent, time-sensitive, elect...

OBJECTIVE Ischemic heart disease accounts for 50% of all cardiovascular deaths and is the leading cause of congestive heart failure. Medical therapy, cardiac assist devices and surgical procedures including heart transplantation have limited efficiency and availability. Stem cell transplantation represents a new therapeutic opportunity for such patients. METHOD Six patients with the diagnosis...

Backgsround: Infective endocarditis (IE) of prosthetic valves is a dire complication cardiac valve replacement surgery and associated with high rates morbidity mortality. Case Summary: A 72-year-old woman multiple comorbidities underwent surgical the aortic mechanical after recurrent IE. After 10 years, IE recurred was surgically replaced bioprosthetic valve. Ten years later, severe heart failu...

OBJECTIVE The Lee-risk index [Lee-index] was developed to predict major adverse cardiac events [MACE]. However, age is not included as a risk factor. The aim was to assess the value of the Lee-index in vascular surgery patients among different age categories. METHODS Of 2642 patients cardiovascular risk factors were noted to calculate the Lee-index. Patients were divided into four age categor...

Myocardial G protein-coupled receptor kinase (GRK)2 is a critical regulator of cardiac beta-adrenergic receptor (betaAR) signaling and cardiac function. Its upregulation in heart failure may further depress cardiac function and contribute to mortality in this syndrome. Preventing GRK2 translocation to activated betaAR with a GRK2-derived peptide that binds G(beta)gamma (betaARKct) has benefited...

Introduction Surgery is a frequent health care intervention with an estimated 6 million non-cardiac surgical procedures performed every year in the United States, with progressive growth in the number of procedures noted each subsequent year(1). Preoperative medical evaluations have been a cornerstone of pre-surgical care planning and patient management. The clinical providers who carry out the...

normal 0 false false false en-us x-none ar-sa background: epilepsy is the second most common type of chronic neurological disease. its diagnosis carries an excess mortality, which is 2-3 times higher than that of general population. mortality rates are increased among patients with uncontrolled seizures . the aim of this study was to characterize the electrocardiogram (ecg) changes during pre-i...

The effects of intravenous infusion of diltiazem on regional blood flow (radioactive microspheres), hemodynamics, and maximum rate of oxygen consumption were evaluated in conscious rats with congestive heart failure caused by large myocardial infarction (n = 10, infarct size 41.8% of left ventricle) and compared with data obtained from rats subjected to sham surgical procedures (n = 9). In both...

T HE internist frequently is called upon by his surgical colleagues for an opinion concerning the risk of anesthesia and of a surgical procedure in a patient who has organic heart disease. A request of this kind carries with it a number of implied questions, among the most important of which are: 1. Does the cardiac abnormality increase the risk of the contemplated procedure? 2. Will the anesth...