نتایج جستجو برای: familial history
تعداد نتایج: 402168 فیلتر نتایج به سال:
An eight-year old boy who was healthy previously had a history of use of trimethoprime-sulphametoxsazole (TPM-SMX) because of diarrhea ten days before presentation. He was hospitalized because painful swelling occured in the legs under this treatment, he had fever and joint pain for the last five days. In his personal history, there was no pathology except for frequent aphtous ulcers in the mou...
Population attributable faction (PAF) shows the proportion of the disease that could be prevented if the cause could be removed. PAFs for most types of familial cancer have not been determined. We used the Swedish Family-Cancer Database on 10.2 million individuals and 688,537 parental and 116,741 offspring cancers to calculate familial risks, proportions of affected individuals, and familial PA...
OBJECTIVE To test the association of family history of diabetes with the adoption of diabetes risk-reducing behaviors and whether this association is strengthened by physician advice or commonly known factors associated with diabetes risk. RESEARCH DESIGN AND METHODS We used cross-sectional data from the 2005-2008 National Health and Nutrition Examination Survey (NHANES) to examine the effect...
BACKGROUND There is increasing evidence that substance use disorders are familial and that genetic factors explain a substantial degree of their familial aggregation. To perform a controlled family study of probands with several different predominant drugs of abuse, including opioids, cocaine, cannabis, and/or alcohol. METHODS The subjects for the present study included 231 probands with depe...
Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS) cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial proportion of the remainder of cases of familial ALS have now been traced to an expansion of the intronic hexanucleotide repeat sequence in C9orf72. This breakthrough provides an opportunity to re-evaluate longstanding c...
INTRODUCTION Hereditary amyloidodis is a rare disease process with a propensity to cause polyneuropathies, autonomic dysfunction, and restrictive cardiomyopathy. It is transmitted in an autosomal dominant manner, with disease onset usually in the 20s-40s. The most common hereditary amyloidogenic protein, transthyretin, is synthesized in the liver and lies on Chromosome 18. Over 80 amyloidogenic...
OBJECTIVES/HYPOTHESIS This study was undertaken to investigate the prevalence, inheritance patterns, and clinical characteristics of familial Meniere's disease (MD) in a South Korean population. STUDY DESIGN Direct interviews, telephone interviews, and reviews of the medical records of definite Meniere's disease patients and their families. METHODS Direct and telephone interviews were perfo...
We would like to report a genetic screening of SDHB, SDHC, SDHD and SDHAF2 genes (hereafter abbreviated to SDHx) in patients with paragangliomas (PGL) and phaeochromocytomas (PCC) from northern Portugal. PGL and PCC are neuroendocrine tumours that can be caused by heterozygous germline loss-of-function mutations in SDHx genes (Gimenez-Roqueplo et al. 2012). The spectrum of germline SDHx mutatio...
BACKGROUND In unselected samples, the diagnosis of major depression (MD) is not highly reliable. It is not known if occasion-specific influences on reliability index familial risk factors for MD, or how reliability is associated with risk for co-morbid anxiety disorders. METHODS An unselected sample of 847 female twin pairs was interviewed twice, 5 years apart, about their lifetime history (L...
BACKGROUND/AIMS Familial occurrence of inflammatory bowel disease (IBD) is well documented. Reports from Western countries have shown a higher familial occurrence of ulcerative colitis (UC) in first- and second-degree relatives than that in the Asian UC population. No data are currently available from the Indian subcontinent in this regard. We present our data on the familial aggregation of UC....
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