BACKGROUND Excessive elevation of arterial blood pressure (BP) at high altitude can be detrimental to our health due to acute mountain sickness (AMS) or some AMS symptoms. This prospective and observational study aimed to elucidate blood pressure changes induced by exposure to high-altitude hypoxia and the relationships of these changes with AMS prevalence, AMS severity, sleep quality and exerc...

Prion diseases are fatal neurodegenerative disorders that are derived from structural changes of the native PrPc. Recent studies indicated that hinokitiol induced autophagy known to major function that keeps cells alive under stressful conditions. We investigated whether hinokitiol induces autophagy and attenuates PrP (106-126)-induced neurotoxicity. We observed increase of LC3-II protein level...

Unguarded tricuspid regurgitation (TR) due to a flail tricuspid leaflet is a rare condition of newborn cyanosis. A high perinatal mortality has been associated with this fatal condition. But, there are feasible surgical repairs to improve survival. We report the case of a male full-term neonate with intractable hypoxia. He had profound tricuspid insufficiency and leaflet prolapse caused by a ru...

Results A 13-years old adolescent girl diagnosed with polyarticular JIA (RF +/ANA-/HLA-B27-) received the first dose of subcutaneous methotrexate in our Day Care centre due to refractoriness to NSAIDs. While she was leaving the building after 10 minutes of medication she developed urticaria, angioedema, shortness of breath and hypoxia (O2 saturation of 85%). After administration of 0.5ml of 1:1...

BACKGROUND Hypersensitivity pneumonitis (HP) is a rare, non-IgE-mediated inflammatory lung disease caused by inhalational exposure to various antigens found in occupational, avocational and home environments. The prognosis is favorable with early detection and prompt removal of the causative agent, and fatalities are unusual. We present a fatal case of HP caused by chronic exposure to Fusarium ...

Background: The mevalonate pathway generates endogenous cholesterol and intermediates including geranylgeranyl pyrophosphate (GGPP). By reducing GGPP production, statins exert pleiotropic or cholesterol-independent effects. potential regulation of homeostasis through dietary intake the interaction with concomitant statin therapy is unknown. Methods: We developed a sensitive high-pressure liquid...

INTRODUCTION To evaluate the benefits of road transport safety projects, planners need the monetary value of averting fatal and severe injuries. Usually, contingent valuation and risk-risk studies have been used. The contexts posed by both survey techniques do not represent the choice situation a driver faces when having to choose among alternative routes with different levels of safety. METH...

Recent reports of treatment of massive digoxin overdosage have emphasized the success of medical therapy. This report describes a fatal outcome to this problem despite aggressive medical management, including pervenous cardiac pacing and draws attention to deficiencies in current treatment of a serious problem.

The aim of the present study was to determine mRNA expression profiles TRAIL-mediated cell death related genes hypoxia-tolerant rodent Nannospalax nehringi under hypoxia. nucleotide and amino acid sequences these were identified. Captured randomly divided into normoxia hypoxia groups. group exposed a 7% O2 + 93% N2 gas mixture for 52 h, while animals in housed normoxic conditions. Total RNAs is...

the undesirable effects and consequences of occupational fatal accidents have placed a great emphasis on applying preventive measures. this study was aimed to analyze and specify the latent causes of occupational fatal accidents in exir chemical plant, urmia - iran in 2008-2009. the analytical tripod-beta method was used. a geographic information system (gis) was then used to determine a list o...