Extracellular cues affect signaling, metabolic, and regulatory processes to elicit cellular responses. Although intracellular signaling, metabolic, and regulatory networks are highly integrated, previous analyses have largely focused on independent processes (e.g., metabolism) without considering the interplay that exists among them. In this paper, we present the recent development of a flux ba...

Predicting behavior of large-scale biochemical networks represents one of the greatest challenges of bioinformatics and computational biology. Computational tools for predicting fluxes in biochemical networks are applied in the fields of integrated and systems biology, bioinformatics, and genomics, and to aid in drug discovery and identification of potential drug targets. Approaches, such as fl...

PURPOSE To report a case of recurrent idiopathic frosted branch angiitis (FBA) successfully treated with adalimumab. CASE REPORT A 14-year-old otherwise healthy boy was referred to the uveitis clinic for bilateral panuveitis with diffuse retinal vascular sheathing and severe macular edema. Extensive work-up including aqueous sampling for detection of viral causes was inconclusive. Two years a...

Small genome sequencing and annotations are leading to the definition of metabolic genotypes in an increasing number of organisms. Proteomics is beginning to give insights into the use of the metabolic genotype under given growth conditions. These data sets give the basis for systemically studying the genotype-phenotype relationship. Methods of systems science need to be employed to analyze, in...

With the advent of high-throughput technologies, the field of systems biology has amassed an abundance of "omics" data, quantifying thousands of cellular components across a variety of scales, ranging from mRNA transcript levels to metabolite quantities. Methods are needed to not only integrate this omics data but to also use this data to heighten the predictive capabilities of computational mo...

The Unified Modeling Language (UML) is the standard design language for developing object oriented applications. It is widely used in the development of complex systems for general-purpose computers. In heterogeneous domains like mechatronics exist a lot of special-purpose programming languages, which are not always easily to map to UML concepts. For such reasons the UML provides an extension m...

Sympathetic ophthalmia is an ocular inflammatory disease commonly associated with penetrating trauma. We report a case of sympathetic ophthalmia who had Dalen-Fuchs nodules on presentation and developed a frosted branch angiitis (FBA)-like picture which is not a known feature of this disease. A 25-year-old male patient was seen 8 months following penetrating trauma to the left eye. He was treat...

Despite the important role of manual dexterity in child development, neurobiological mechanisms associated with childhood remain unclear. We leveraged fixel-based analysis (FBA) to examine longitudinal association between and development white matter structural properties corticospinal tract (CST). High angular diffusion weighted imaging (HARDI) data were acquired for 44 right-handed typically ...

The results of cyclic, differential pulse and square wave voltammetric studies four ferrocene derivatives, i.e., 4-ferrocenyl-3-methyl aniline (FMA), 3-Chloro-4-ferrocenyl (CFA), 4-ferrocenyl (FA) ferrocenyl benzoic acid (FBA) on carbon electrode, revealed that the redox behavior these compounds is sensitive to pH, concentration, scan number rate. One electron, diffusion controlled, with a quas...

A novel synthesis of 4-[(18)F]fluorobenzylamine ([(18)F]FBA) by means of transition metal-assisted sodium borohydride reduction of 4-[(18)F]fluorobenzonitrile ([(18)F]FBN) is described. This approach could successfully be extended to borohydride exchange resin (BER) enabling a viable option for use in automated syntheses. [(18)F]FBA was used for the synthesis of 4-[(18)F]fluorobenzylamine-based...