The amygdala plays a critical role in fear conditioning, a model of emotional learning and cue-induced anxiety. In the lateral amygdala, fear conditioning is associated with an enduring increase in synaptic strength mediated through AMPA receptors and with a reduction in paired-pulse facilitation, reflecting an increased probability of neurotransmitter release. Here we show that NMDA-mediated t...

Theta oscillations are considered crucial mechanisms in neuronal communication across brain areas, required for consolidation and retrieval of fear memories. One form of inhibitory learning allowing adaptive control of fear memory is extinction, a deficit of which leads to maladaptive fear expression potentially leading to anxiety disorders. Behavioral responses after extinction training are th...

PURPOSE/OBJECTIVES To identify demographic and treatment characteristics associated with postoperative fear of lymphedema. DESIGN Prospective cohort study. SETTING Outpatient breast clinic at a comprehensive cancer center in the northeastern United States. SAMPLE 324 patients undergoing treatment for unilateral breast cancer. METHODS Women with breast cancer were prospectively screened ...

For many decades, classically conditioned fear has provided fertile ground for neuroscientists interested in learning and memory. The paradigms are conceptually straightforward, the protocols robust, and the relevance to the human (and animal) condition unquestionable. Fear, or something very like it, is probably as old as the animal kingdom. One of the great advantages of being an animal, and ...

The reasons why previous studies of fear of crime yield different conclusions regarding age differences are examined. Data from a national survey of adults are used to assess whether older adults manifest the highest levels of fear of crime. No significant relationship was found between age and the commonly used indicators of fear of crime in many previous studies when controlling for relevant ...

In the standard model of pavlovian fear learning, sensory input from neutral and aversive stimuli converge in the lateral nucleus of the amygdala (LA), in which alterations in synaptic transmission encode the association. During fear expression, the LA is thought to engage the central nucleus of the amygdala (CE), which serves as the principal output nucleus for the expression of conditioned fe...

Understanding the molecular and cellular process specifically regulated during fear memory consolidation and extinction is a critical step toward development of new strategies in the treatment of human fear disorders. Here we used inhibitory component of AP-1 transcription factor, JunB, in order to map brain regions where JunB-dependent transcription is regulated during consolidation and extinc...

The roles of the dorsal hippocampus and the central nucleus of the amygdala in the expression of contextual fear were assessed using two measures of conditioned fear: freezing and fear-potentiated startle. A discriminable context conditioning paradigm was developed that demonstrated both conditioned freezing and fear-potentiated startle in a context paired previously with foot shock, relative t...

This article studies the function of the ‘fear of God’ idea in the book of Job. It is argued that, despite the difference in terminology, the ‘fear of God’ is equivalent to the ‘fear of the LORD’ concept of Proverbs. The location of the motif in the final form of the book of Job suggests that the ‘fear of God’ is not being proposed as the answer to Job’s dilemma. Rather, Job is one who maintain...

Disrupting reconsolidation seems to be a promising approach to dampen the expression of fear memory. Recently, we demonstrated that disrupting reconsolidation by a pharmacological manipulation specifically targeted the emotional expression of memory (i.e., startle response). Here we test in a human differential fear-conditioning paradigm with fear-relevant stimuli whether the spacing of a singl...