The development of direction selectivity in the visual system depends on visual experience. In the developing Xenopus retinotectal system, tectal neurons (TNs) become direction selective through spike timing-dependent plasticity (STDP) after repetitive retinal exposure to a moving bar in a specific direction. We investigated the mechanism responsible for the development of direction selectivity...

introduction: feedback is very important in education and can help quality in the training process and orient the trainees in clinical contexts. this study aimed to assess the residents’ points of view about feedback in clinical education at shiraz university of medical sciences. methods: the sample of this study included 170 medical residents attending medical workshops in shiraz university of...

The origin of orientation selectivity in the responses of simple cells in cat visual cortex serves as a model problem for understanding cortical circuitry and computation. The feed-forward model posits that this selectivity arises simply from the arrangement of thalamic inputs to a simple cell. Much evidence, including a number of recent intracellular studies, supports a primary role of the tha...

Activation of factor XI (FXI) by thrombin in vivo plays a role in coagulation by providing an important positive feedback mechanism for additional thrombin generation. FXI is activated in vitro by thrombin, or FXIIa in the presence of dextran sulfate. In this report, we investigated the effect of 2-glycoprotein I ( 2GPI) on the activation of FXI. 2GPI bound FXI in vitro and inhibited its activa...

We used in vivo intracellular recording techniques in order to provide evidence about the source of postsynaptic inhibition in the rat entorhinal cortex and subicular complex. Several different structures in the basal forebrain and hippocampus were electrically stimulated in order to activate inhibition by different pathways. This allowed a test of 2 different neuronal circuit models: feedback ...

PURPOSE The inhibition of c-Src results in a striking reduction in cancer cell invasion, but the effect on cell survival is modest. Defining mechanisms that limit apoptosis following c-Src inhibition could result in an ideal therapeutic approach that both inhibits invasion and leads to apoptosis. In this regard, we discovered a novel feedback loop that results in STAT3 reactivation following su...

Purpose: The inhibition of c-Src results in a striking reduction in cancer cell invasion, but the effect on cell survival is modest. Defining mechanisms that limit apoptosis following c-Src inhibition could result in an ideal therapeutic approach that both inhibits invasion and leads to apoptosis. In this regard, we discovered a novel feedback loop that results in STAT3 reactivation following s...

Cell line models of the activated B cell-like (ABC) subtype of diffuse large B cell (DLBCL) depend on both NF-κB and phosphatidylinositol 3-kinase (PI3K) signaling pathways for survival, especially those with gain-of-function B cell receptor (BCR) mutations. Here we show that these cells depend specifically on the PI3Kδ isoform, but that PI3K pathway interruption by PI3Kδ inhibitors is short-li...

The signal transfer of a neuronal network is shaped by the local interactions between the excitatory principal cells and the inhibitory interneurons. We investigated with a simple lumped model how feedforward and feedback inhibition in!uence the steady-state network signal transfer. We analyze how the properties of inhibition a"ect the input/output space of the network and compare the results w...

recent interaction studies havefocused on the relationship between interactional feedback and l2 development.despite the large body of knowledge in this regard, few studies have examinedlearners’ preferences for interactional feedback. besides, different findingshave been reported concerning learners’ preferences for feedback and none hasexamined the factors accounting for the variation in the ...