To our knowledge, there is no report on long-term reproductive and developmental side effects in the offspring of mothers treated with a widely used chemotherapeutic drug such as doxorubicin (DXR), and neither is there information on transmission of any detrimental effects to several filial generations. Therefore, the purpose of the present paper was to examine the long-term effects of a single...

OBJECTIVE Self-harm and suicide increase in times of economic recession, but little is known about why people self-harm when in financial difficulty, and in what circumstances self-harm occurs. This study aimed to understand events and experiences leading to the episode of self-harm and to identify opportunities for prevention or mitigation of distress. SETTING Participants' homes or universi...

The term cancer has been concomitant with despair, agony, and dreadful death. Like many other diseases, herbal therapy has been used to prevent or suppress cancer. The present study investigated the capability of the decoction of Teucrium polium L. from Lamiaceae family to protect liver cells against hepatocellular carcinoma in carcinogenesis-induced animal model. After 28 weeks of treatment wi...

The consequences of a “brain injury” on any individual, family or relationship are far reaching. A brain injury not only impacts who the person once was, but also how the family will be together. Memory, behavioural, emotional, and personality changes are often difficult to accept and understand. Many family members feel that their loved ones are “forever changed” and find it hard to accept wha...

Yevgeny Zamyatin’s novel We is one of the most important “UtopianDystopian” novels of the first half of the 20th century and was originally considered a criticism of the Communism established in Russia after the Bolshevik Revolution, during the so-called War Communism, with the loss of revolutionary thrust and new stifling social rules . As a result, critics have seen We as a dystopian novel, i...

This Is a Story about Controls Unraveling the pathogenesis of a complex disease is daunting. Variation in multiple genes and multiple environmental factors could be at play, as could variation in the interactions of these risk factors with each other. Lest you despair, Cadwell et al. prove that it is possible to reveal features of the disease process through a careful set of experiments with go...

BACKGROUND AND PURPOSE Tetrahydro-N, N-dimethyl-5, 5-diphenyl-3-furanmethanamine hydrochloride (ANAVEX1-41) is a potent muscarinic and sigma(1) (sigma (1)) receptor ligand. The sigma (1) receptor modulates glutamatergic and cholinergic responses in the forebrain and selective agonists are potent anti-amnesic and antidepressant DRUGS. WE HAVE HERE ANALYSED THE SIGMA (1) COMPONENT IN THE BEHAVIOU...

OBJECTIVES The disaster of the Sewol ferry that sank at sea off Korea's southern coast of the Yellow Sea on April 16, 2014 was a tragedy that brought grief and despair to the whole country. The aim of this study was to evaluate the mental health effects of this disaster on the community of Ansan, where most victims and survivors resided. METHODS The self-administered questionnaire survey was ...