Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form in a biologically functional way. Proteinprotein interactions are intrinsic to virtually every cellular process. Interactions between proteins have been studied through a number of high-throughput experiments and have also been predicted through an array of computational me...

We have determined the DNA sequence of a cloned cDNA that is complementary to the mRNA for the 50 kilodalton (kd) human epidermal keratin. This provides the first amino acid sequence for a cytoskeletal keratin. Comparison of this sequence with those of other keratins reveals an evolutionary relationship between the cytoskeletal and the microfibrillar keratins, but shows no homology to matrix or...

The presence of spectrin and ankyrin-like proteins was investigated during the differentiation and maturation of spermatozoa in mammalian species which have previously been studied for actin and calmodulin. These actin-binding proteins were characterized by immunoblotting and localized by immunoelectron microscopy. Neither spectrin nor ankyrin could be detected in the F-actin rich subacrosomal ...

Solitary fibrous tumors are well described in the pleura, but rare extra-pleural neoplasms have been reported. We describe a patient with a solitary left renal fibrous tumor who after undergoing a nephrectomy, presented 8 years later with a contralateral metachronous solitary fibrous tumor. Malignant metastatic extra-pleural solitary fibrous tumors are extremely rare, and to our knowledge, this...

Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsalpha subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentia...

Bacterial genomic DNA is packed within the nucleoid of the cell along with various proteins and RNAs. We previously showed that the nucleoid in log phase cells consist of fibrous structures with diameters ranging from 30 to 80 nm, and that these structures, upon RNase A treatment, are converted into homogeneous thinner fibers with diameter of 10 nm. In this study, we investigated the role of ma...

T HERE are nearly 50 different intermediate filament (IF) proteins of five major types (for reviews, see references 16, 23, and 59). Four of the IF types are cytoplasrnic, and they are expressed differentially in all tissues at various stages of embryonic and adult development. Type V IF proteins are the nuclear lamins, which form a fibrous meshwork on the inner surface of the nuclear membrane,...

Fibrous dysplasia is a condition leading to abnormal differentiation of osteoblasts which leads to replacement of normal bone with fibrous stroma [1-3]. It may involve single bone (monostotic) or multiple bones (polyostotic). It may affect any bone however; skull and ribs are the commonest [2,4-6]. It is usually asymptomatic and is an incidental finding. It may become symptomatic when complicat...

CONTEXT Solitary fibrous tumor is an uncommon spindle cell tumor which can occur in a variety of locations. Four cases of pancreatic solitary fibrous tumor have been reported in the literature. CASE REPORT We report the fifth case of pancreatic solitary fibrous tumor in a 78-year-old woman who presented with back pain and weight loss. Imaging studies were suggestive of an endocrine tumor. End...