Multi-fidelity prototyping combines within a single user interface prototype several elements whose representations are reproduced with different levels of fidelity with respect to the final user interface: no fidelity at all, low fidelity, medium fidelity, and high fidelity. In order to effectively and efficiently support multi-fidelity, an original set of techniques is defined and discussed: ...

We study the crossover of the quantum Loschmidt echo (or fidelity) from the golden-rule regime to the perturbation-independent exponential decay regime by using the kicked top model. It is shown that the deviation of the perturbation-independent decay of the averaged fidelity from the Lyapunov decay results from quantum fluctuations in individual fidelity, which are caused by the coherence in t...

A fidelity trade environment was demonstrated by using it to simulate a decision making process for a transport aircraft. This scenario was not possible without the fidelity trade environment. The role of system feedback and coupling in error stability was also investigated. A sensitivity approach which relies on the system sensitivity matrix was used to rapidly approximate the propagation of e...

Addressing complex chronic disease prevention, like childhood obesity, requires a multi-level, multi-component culturally relevant approach with broad reach. Models are lacking to guide fidelity monitoring across multiple levels, components, and sites engaged in such interventions. The aim of this study is to describe the fidelity-monitoring approach of The Children's Healthy Living (CHL) Progr...

Simulation is a promising pedagogical tool in the area of medical education. High- fidelity simulators can reproduce realistic environments or clinical situations. This allows for the practice of teamwork and communication skills, thereby enhancing reflective reasoning and experiential learning. Use of high-fidelity simulators is not limited to the medical and aeronautical fields, but has devel...

Mutation rates should be governed by at least three evolutionary factors: the need for beneficial mutations, the benefit of minimizing the mutational load and the cost of replication fidelity. RNA viruses show high mutation rates compared with DNA micro-organisms, and recent findings suggest that the cost of fidelity might play a role in the evolution of increased mutation rates. Here, by analy...

One of the main challenges of co-simulating hardware-in-the-loop systems in realtime over the Internet is the fidelity of the simulation. The stochastic delay of the Internet may significantly distort the dynamics of the network-integrated system. This paper presents the development of an iterative learning control based approach to improve fidelity in such network-integrated systems. Towards t...

One of the main challenges of co-simulating hardware-inthe-loop systems in real-time over the Internet is the fidelity of the simulation. The dynamics of the Internet may significantly distort the dynamics of the network-integrated system. This paper presents the development of an iterative learning control based approach to improve fidelity of such networked system integration. Towards this en...

To study fidelity of RNA polymerase II (Pol II), we analyzed properties of the 6-azauracil-sensitive and TFIIS-dependent E1103G mutant of rbp1 (rpo21), the gene encoding the catalytic subunit of Pol II in Saccharomyces cerevisiae. Using an in vivo retrotransposition-based transcription fidelity assay, we observed that rpb1-E1103G causes a 3-fold increase in transcription errors. This mutant sho...

The fidelity of DNA replication by DNA polymerase (DNAP) has long been an important issue in biology. While numerous experiments have revealed details of the molecular structure and working mechanism of DNAP which consists of both a polymerase site and an exonuclease (proofreading) site, there were quite few theoretical studies on the fidelity issue. The first model which explicitly considered ...