Hugo: ALOX5 Other names: 5-LO; EC 1.13.11.34; leukotriene A4 synthase; 5LPG; LOG5 Location: 10q11.2 Local order: Genes flanking ALOX5, in centromere to telomere direction on 10q11, are: OR6D1P 10q11.21 olfactory receptor, family 6, subfamily D, member 1 pseudogene. LOC643413 10q11.21 hypothetical protein LOC643413. OR13A1 10q11.21 olfactory receptor, family 13, subfamily A, member 1. ALOX5 10q1...

EEG-BCIs have been well studied in the past decades and implemented into several famous applications, like P300 speller and wheelchair controller. However, these interfaces are indirect due to low spatial resolution of EEG. Recently, direct ECoG-BCIs attract intensive attention because ECoG provides a higher spatial resolution and signal quality. This makes possible localization of the source o...

The rules of engagement between zinc finger transcription factors and DNA have been partly defined by in vitro DNA-binding and structural studies, but less is known about how these rules apply in vivo Here, we demonstrate how a missense mutation in the second zinc finger of Krüppel-like factor-1 (KLF1) leads to degenerate DNA-binding specificity in vivo, resulting in ectopic transcription and a...

Robotic hands built for manipulation are often anthropomorphic but not anatomically accurate. We are constructing an anatomically-correct testbed (ACT) of the human hand to understand its mechanisms, function, and control. We have previously demonstrated that an accurate model of the extensor mechanism in the ACT Hand is crucial in realizing the human-like finger movements. Here, we present des...

Steroid hormone receptors activate specific gene transcription by binding as hormone-receptor complexes to short DNA enhancer-like elements termed hormone response elements. The DNA-binding domain (termed region C) is a highly conserved 66-amino acid region that contains two subregions (CI and CII) analogous to the "zinc fingers" of transcription factor IIIA. Using chimeric estrogen receptors, ...

The Kruppel-like factor family is a group of zinc finger containing transcription factors, which are highly homologous with the Drosophila Kruppel protein. The feature that distin‐ guishes the KLF family from other zinc finger containing transcriptional factors is the pres‐ ence of three highly conserved C2H2 containing zinc finger motifs at the C-terminus [1-3]. These fingers enable KLFs to bi...

Description 540 and 673 amino acids, 62 and 74 kDa (PLZFa and b respectively); Krüppel-like zinc finger protein; N-term BTB/POZ domain (protein-protein interaction motif) and 9 zinc finger domains in C-term. Expression Highly specific for hematopoietic cells; during mouse development, PLZF is expressed in embryonic tissus, giving rise to hematopoietic progenitors; in man, PLZF is expressed in C...

Biometric systems identify a person through physical traits or verify his/her identity through automatic processes. Various systems were used over years including systems like fingerprint, iris, facial images, hand geometry and speaker recognition. For biometric systems successful implementation, it has to address issues like efficiency, accuracy, applicability, robustness and universality. Sin...

Polyacrylonitril (PAN)-supported chitosan (CS) nanocomposite membranes were prepared by cross-linking the CS with 3-aminopropyl-triethoxysilane (APTEOS) via sol-gel method. Pervaporative performances of the CS-SiO2/PAN membrane for dehydration of aqueous alcohol solutions were investigated. From SEM cross-sectional images of the membrane, the spongy pores and the finger-like pores we...

PATZ1 is a zinc finger protein, belonging to the POZ domain Krüppel-like zinc finger (POK) family of architectural transcription factors, first discovered in 2000 by three independent groups. Since that time accumulating evidences have shown its involvement in a variety of biological processes (i.e., embryogenesis, stemness, apoptosis, senescence, proliferation, T-lymphocyte differentiation) an...