We show that point-neuron models with a Heaviside firing rate function can be ill posed. More specifically, the initial-condition-to-solution map might become discontinuous in finite time. Consequently, if finite precision arithmetic is used, then it is virtually impossible to guarantee the accurate numerical solution of such models. If a smooth firing rate function is employed, then standard O...

Introduction: Previously, we demonstrated that i.p. injection of aqueous extract prepared from aerial parts of Drosera Spatulata (Droseraceae) can induced remarkable analgesia in both phases of formalin test in rats. Because, analgesia induced in acute phase of formalin test mainly mediated by activation of central analgesic mechanisms and also paragigantocellularis (PGi) nucleus is part of bra...

We propose a novel formulation of the firing squad synchronization problem. In this formulation we may use more than one general state and the general state to be used is determined by the boundary condition of the general. We show that the usual formulation and the new formulation yield different minimum firing times for some variations of the problem. Our results suggest that the new formulat...

Multisecond oscillations in firing rate in the basal ganglia: robust modulation by dopamine receptor activation and anesthesia. Studies of CNS electrophysiology have suggested an important role for oscillatory neuronal activity in sensory perception, sensorimotor integration, and movement timing. In extracellular single-unit recording studies in awake, immobilized rats, we have found that many ...

The aim of this study was to measure the effects of synaptic input on motoneuron firing rate in an unanesthetized cat preparation, where activation of voltage-sensitive dendritic conductances may influence synaptic integration and repetitive firing. In anesthetized cats, the change in firing rate produced by a steady synaptic input is approximately equal to the product of the effective synaptic...

INTRODUCTION Loss of inhibitory output from Purkinje cells leads to hyperexcitability of the Deep Cerebellar Nuclei (DCN), which results in cerebellar ataxia. Also, inhibition of small-conductance calcium-activated potassium (SK) channel increases firing rate of DCN, which could cause cerebellar ataxia. Therefore, SK channel activators can be effective in reducing the symptoms of this disease, ...

Introduction: Purkinje Cell (PC) output displays a complex firing pattern consisting of high frequency sodium spikes and low frequency calcium spikes, and disruption in this firing behavior may contribute to cerebellar ataxia. Riluzole, neuroprotective agent, has been demonstrated to have neuroprotective effects in cerebellar ataxia. Here, the spectral analysis of PCs firing in control, 3-acety...

The intrinsic properties of tonically firing neurons in the cochlear nucleus contribute to representing average sound intensity by favoring synaptic integration across auditory nerve inputs, reducing phase locking to fine temporal acoustic structure and enhancing envelope locking. To determine whether tonically firing neurons of the avian cochlear nucleus angularis (NA) resemble ideal integrato...