To access P1-farnesyl-P2-indicator diphosphates, more efficient methods for the synthesis of farnesyl-phosphate and diphosphates were developed. The procedures reported here provide more flexible conditions than the conventional imidazolide and morpholidate coupling methods. Milder conditions for the synthesis of sensitive allylic diphosphates and greatly improved reaction efficiencies provide ...

A flexible diastereoselective approach to trans-(3S)-hydroxyprolinol derivatives is described, which is based on the samarium diiodide-mediated reductive coupling of the chiral 1-pyrroline N-oxide (nitrone)(S)-10 with carbonyl compounds. The reductive hydroxyalkylation of nitrone 10 with ketones and aromatic aldehydes is highly diastereoselective in establishing the C-2 chiral center of the pyr...

Due to their small size and flight regime, coupling of aerodynamics, structural dynamics, and flight dynamics is critical for Micro Aerial Vehicles. This paper presents a computational framework for simulating structural models of varied fidelity and a Navier-Stokes solver, aimed at simulating flapping and flexible wings. The structural model utilizes either (i) the in-house developed UM/NLABS,...

A modular web-based approach for simulation-based optimization of multi-physics systems is described. The basic principle is the flexible coupling of an optimization toolbox with a variety of simulators via LAN or Internet. The structure and basic solutions for tool integration, communication, and user interaction are discussed. For a practical optimization task the usability of the approach is...

A new type of flexible organic tribotronic transistor memory is proposed, which can be written and erased by externally applied touch actions as an active memory. By further coupling with an organic light-emitting diode (OLED), a visible and wearable touch monitoring system is achieved, in which touch triggering can be memorized and shown as the emission from the OLED.

The coupling and domain decomposition techniques combined with extensive use of object-oriented programming techniques will result in an efficient, flexible, and systematic process for producing parallel partial differential equations codes. This paper discusses important issues regarding the implementation of an object-oriented framework for simulating incompressible flow using parallel comput...

For complex oligosaccharides, which are relatively rigid with modest excursions from a single minimum energy conformation, it is straightforward to build conformational models from NOE data. Other oligosaccharides are more flexible with transitions between distinct minima separated by substantial energy barriers. We show that modeling based on scalar coupling data is superior to NOE-based model...