An inert hydrophobic buoyant coated-core was developed as floating drug delivery system (FDDS) for sustained release of cisapride using direct compression technology. Core contained low density, porous ethyl cellulose, which was coated with an impermeable, insoluble hydrophobic coating polymer such as rosin. It was further seal coated with low viscosity hydroxypropyl methyl cellulose (HPMC E15)...

Gastroretentive dosage forms (GRDF) has received significant interest in the past few decades as they can improve the limitation of most conventional and oral controlled release drug delivery system related to fast gastric-emptying time. An optimum GRDF system can be defined as a system which retains in the stomach for a sufficient time interval against all the physiological barriers, releases ...

The aim of present study involves preparation and characterization of floating microspheres using trimetazidin dihydrochloride as a model drug to increase the residence time in the stomach without contact with the mucosa, Floating microspheres were prepared by the capillary extrusion technique using chitosan as polymer and sodium lauryl sulphate as cross linking agent. The surface morphology of...

Objective: The objective was formulation and characterization of low-density gastro-retentive microspheres of Acyclovir (ACV) using hydroxyl propyl methyl cellulose to enhanced retention time and bioavailability. Materials and Methods: HPMCK4M was used as polymer for forming microspheres and Poly Vinyl Alcohol as stabilizing agent. The microspheres were characterized with respect to their morph...

Ondansetron is a serotonin (5HT3) receptor antagonist used for the prevention and treatment of postoperative nausea vomiting. It available in many dosage forms market. Various analytical methods determination have been studied this review article such as UV spectroscopy, mass high-performance liquid chromatography, thin layer new electrospray ionization spectrometry etc. human plasma can be est...

(TDDS), additionally called ‘ Transdermal patches,’ square measures dose form design to deliver a The human skin is readily accessible surface for drug delivery. Drug Delivery Systems therapeutically effective quantity of across patients skin. In order therapeutics agents through the systemic effect, comprehensive morphological , biophysical and physicochemical properties are be considered. del...

In order to increase bioavailability, stability, and target the drug a specific region at predetermined rate, floating microspheres, multi-unit delivery systems, are designed accomplish controlled or delayed administration. clinical practise, drugs that have an upper small intestine absorption window may benefit most from system with extended stomach residence period. The non-uniformity of medi...