Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study...

Praziquantel is the only drug available for the treatment of Opisthorchis viverrini infections. Tribendimidine has emerged as a potential treatment alternative; however, its pharmacokinetic (PK) properties have not been sufficiently studied to date. Via two phase IIa dose-finding studies, 68 O. viverrini patients were treated with 25- to 600-mg doses of tribendimidine using 50- and 200-mg table...

Carvedilol (CVD) is an antihypertensive agent with a short half-life, pH-dependent solubility, and narrow absorption window. The purpose of this research was to prepare a floating-drug delivery-system of carvedilol to increase its half-life. The present study investigates the preparation of carvedilol-floating microspheres, evaluates the floating-drug delivery-system (FDDS) (by scanning electro...

Intragastric buoyant tablets, i.e., gastro retentive drug delivery systems of Amoxycillin trihydrate were prepared with the objective to obtain site-specific drug delivery for the stomach and to extend its duration of action. The sustained release of amoxicillin is desired because of its short biological half-life. Part icularly to treat Helicobacter pylori infections, the sustained release is ...

The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various release retardants. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Floating tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK4M, HPMCK15M and HPMCK100M with effervescent mixtures by direct compression technique. Totally 9 formulations were...

ABSTRACT: Floating inductor circuits using minimum number of passive elements namely two resistors and one capacitor is reviewed in this paper. All the circuits considered in this paper are floating. Previously reported non-floating circuits are modified to be floating and new floating circuits are introduced as well. The active elements used in this paper are floating conveyor building blocks ...

In this thesis, the strength-enhancing mechanisms of dry binders in direct compression were studied. The systems investigated were binary mixtures containing various compounds and binders. Among the binders used were a series of different molecular weights of polyethylene glycol. The proposed simplified tablet model describing the fracture path in a tablet during strength testing offers an expl...

background: the poisoning is mostly due to suicide and is observed in younger age groups. the systemic manifestations of alp poisoning are common but pernicious manifestations of them are cardiotoxicity, shock, and ards. the clinical hallmark of cardiotoxicity is arrhythmia. the aim of this study was to investigate cardiac arrhythmias in patients poisoned with alp who were admitted to razi hosp...