It has been demonstrated that simultaneous exposure of Daphnia magna to suspended solids and a carbamate pesticide potentiates the toxic response to the pesticide. The toxicodynamics between these stressors were investigated to determine possible mechanisms of interaction. Three experimental series were conducted with D. magna to determine: the effect of food availability on carbofuran toxicity...

We present the results of an extensive numerical study of the orbital evolution of small solids, ranging from dust grains to km-sized objects, in the vicinity of a local density enhancement in a non-uniform solar nebula. In a previous study we have shown that when the motions of such solids are restricted to the midplane of the nebula, the combined effect of gas drag and pressure gradients caus...

Spectral domain optical coherence tomography (SDOCT) images have been used to investigate the mechanism of optical clearing in flowing blood using dextrans. The depth reflectivity profiles from SDOCT indicate that dextrans become increasingly more effective in reducing scattering in flowing blood, except for 5 mgdl(-1) of Dx500, with increasing molecular weights (MW 70,000 and 500,000) and conc...

Optical properties of flowing blood were analyzed using a photon-cell interactive Monte Carlo (pciMC) model with the physical properties of the flowing red blood cells (RBCs) such as cell size, shape, refractive index, distribution, and orientation as the parameters. The scattering of light by flowing blood at the He-Ne laser wavelength of 632.8 nm was significantly affected by the shear rate. ...

“Pharmaceutical Solids” discusses scientific principles associated with pharmaceutical solids useful to practitioners in validation and compliance. We intend this column to help the understanding of principles associated with pharmaceutical solids and to be a useful resource for daily work applications. Enhanced process understanding is an important objective of the quality-by-design initiative...