The integration of continuous unit operations imposes a challenge on the pharmaceutical companies aspiring to achieve plant-wide manufacturing due additional complexity dynamic interactions, process control and quality assurance. To overcome this challenge, flowsheet modeling emerged as viable tool gain deeper knowledge. In work, model integrated acetylsalicylic acid (ASA) was formed based real...

Bauxite residue is a high-iron waste of the alumina industry with significant contents scandium, aluminum, and titanium. This study focuses on recovery Sc, Al, Ti, Si from iron-depleted bauxite (IDBR) into valuable products. Iron depletion was carried out using reduction roasting followed by low-intensity magnetic separation to enrich in Sc reduce an adverse effect iron scandium extraction. Hyd...

A model that captures realistic viral growth dynamics has been developed based on a continuous and semi-continuous production of an influenza virus. This considers parameters such as latency. It also the lag observed during early viruses in culture explains later-phase dynamics. Furthermore, sensitivity analysis was performed to investigate effects each input output. revealed defective interfer...

Fuel cells are electrochemical devices that conventionally used to convert the chemical energy of fuels into electricity while producing heat as a byproduct. High temperature fuel such molten carbonate and solid oxide produce significant amounts can be for internal reforming natural gas mixtures which rich in hydrogen, also electricity. This opens up possibility using high systems designed flex...

Resource consumption is an important topic for steelmaking industry, which spending significant efforts to reduce its environmental impact and improve competitiveness. Water largely exploited in steelworks indirect direct cooling, specific surface treatment, fumes washing cooling. It already reused recycled after restoring quality through treatments temperature and/or pollutant reduction. Howev...

The high cost of energy resources requires implementation high-efficient techniques for production. In order to successfully solve the problem intensification, resource and saving in production processes alkyd resins, electric heaters technological flowsheet was proposed. A high-temperature ceramic with heat resistance proposed its thermal conductivity coefficient estimated working conditions. ...

In this work a methodology is presented for the rigorous optimization of nonlinear programming problems in which the objective function and (or) some constraints are represented by noisy implicit black box functions. The special application considered is the optimization of modular process simulators in which the derivatives are not available and some units operations introduce noise preventing...

In this article we propose a combined signed directed graph (SDG) and qualitative trend analysis (QTA) framework for incipient fault diagnosis. The SDG is the rst level in our framework and provides a possible candidate set of faults based on the incipient response of the process. The search for the actual fault is performed based on a QTA, which uses the temporal evolution of the sensors for f...