There is always rapid volume restitution of the accumulated interstitial fluid after a VCP (venous congestion plethysmography) protocol. It has been suggested that backward extrapolation of the relationship between applied hydrostatic pressure and fluid filtration may give a measure of tissue J (vL) (lymph flow); if so, this could be of immense value in pathophysiological investigations. We hyp...

Iotrol, a new nonionic, water-soluble, hexiodinated dimeric contrast medium for myelography, was used in clinical trials in 29 patients. The purpose of the study was to acquire information on local and general tolerance, distribution and excretion, and image quality. Preliminary results show that iotrol is well suited for lumbar and thoracolumbar myelography. Side effects observed with the use ...

1. Brattleboro rats with hereditary diabetes insipidus were maintained in metabolism cages for 12-14 days. During the final 5-7 days hydrochlorothiazide was added to the food of half the animals, resulting in a sustained antidiuresis. At the end of this time all rats were anaesthetized and their renal function was investigated. 2. Water, sodium and potassium excretion rates during anaesthesia w...

Kidney diseases involving urinary loss of large essential macromolecules, such as serum albumin, have long been thought to be caused by alterations in the permeability barrier comprised of podocytes, vascular endothelial cells, and a basement membrane working in unison. Data from our laboratory using intravital 2-photon microscopy revealed a more permeable glomerular filtration barrier (GFB) th...

The molecular structure of a sulfated glycoprotein from chick chorioallantoic fluid has been investigated. The effect of alkali and alkali-borohydride under various conditions has been shown to lead to quantitatively and qualitatively different products of elimination and reduction. The carbohydrate chains of the products, by gel filtration, were heterogeneous, ranging from an average molecular...

The individual processes involved in interstitial fluid volume and protein regulation (microvascular filtration, lymphatic return, and interstitial storage) are relatively simple, yet their interaction is exceedingly complex. There is a notable lack of a first-order, algebraic formula that relates interstitial fluid pressure and protein to critical parameters commonly used to characterize the m...

The Na/H exchanger isoform 3 (NHE3) is expressed in the proximal tubule and thick ascending limb and contributes to the reabsorption of fluid and electrolytes in these segments. The contribution of NHE3 to fluid reabsorption was assessed by micropuncture in homozygous ( Nhe3 -/-) and heterozygous ( Nhe3 +/-) knockout mice, and in their wild-type (WT, Nhe3 +/+) littermates. Arterial pressure was...

A review on pleural space is certainly most welcome, for the simple reason that on opening a textbook of physiology the concepts concerning pleural fluid turnover date back to 1927 [1]. The same comment, in fact, applies in general to microvascular water and solute exchange. This appears particularly misleading, considering the major advances achieved in the field over the last 70 yrs. Around t...

Designing drilling fluids for drilling in deep gas reservoirs and geothermal wells is a major challenge. Cooling drilling fluids and preparing stable mud with high thermal conductivity are of great concern. Drilling nanofluids, i.e. a low fraction of carbon nanotube (CNT) well dispersed in mud, may enhance the mixture thermal conductivity compared to the base fluids. Thus, they are potentially ...

Introduction: Endodontic treatment failure is caused by the leakage of microorganisms and endotoxins, which leads to pathological lesions. Adequate seal of the root canal is essential to preventing recontamination and ensuring the long-term clinical success rate. Mineral trioxide aggregate (MTA) and calcium-enriched mixture cement (CEM) are common types of cement with adequate ...