Fluorination has gained an increasingly important role in drug discovery and development. Here we describe a versatile strategy that combines cytochrome P450-catalyzed oxygenation with deoxofluorination to achieve mono- and polyfluorination of nonreactive sites in a variety of organic scaffolds. This procedure was applied for the rapid identification of fluorinated drug derivatives with enhance...

On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical ...

A Pd(II)-catalyzed direct selective fluorination reaction of carboranes using a F(+) reagent has been developed, leading to a series of polyfluorocarboranes in high isolated yields. The mechanism involving electrophilic B-H activation, oxidation of Pd(II) by F(+) species, and reductive elimination is proposed.

Fluorinated Bis-GMA was synthesized and used with other commercially available fluorinated monomers and diluents to prepare hydrophobic composites. The composites were formulated as one-paste systems and were polymerized using blue light. Mechanical properties and water-related qualities were determined. Fluorination generally improved the hydrophobicity of the composites, but there was no clea...

Exploration of novel chemical space, a modern trend in medicinal chemistry, is heavily reliant on synthetic access to new and interesting building blocks. In this direction, the following work describes an expedient synthesis of one such moiety, 3-fluorobicyclo[1.1.1]pentan-1-amine, by employing radical fluorination.

An efficient protocol for the selective fluorination of benzylic C-H bonds is described. The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources, such as triethylamine trihydrofluoride and KF. Reaction rates are sufficiently high (30 min) to allow adoption for the incorporation of (18)F fluoride sources for PET imaging applications.

The unique and desirable properties of fluorinated compounds in pharmaceutical, agrochemical, materials sciences have driven the development remote fluorination methods. In particular, C–C cleavage/fluorination cyclic molecules recently emerged as one most reliable approaches, allowing efficient construction otherwise inaccessible molecules. While serving a powerful platform, many ring-opening ...

The fluorination modification improved the oxidation voltage of GPE and facilitated movement polymer chain transfer Li + . capacity retention NCM811|0.4TGD-0.4TFM-TCGG-SiO 2 NF|Li cell reached 91% after 260 cycles at 2C.

Fluorination of BN nanotubes has been performed using a catalytic growth method, which leads to the appearance of markedly curved fluorine-doped BN sheets and converts originally insulating BN nanotubes to semiconductors, as confirmed by the comparative electron transport four-probe measurements on doped and undoped individual BN nanotubes.

A simple transformation of alkynol or enyne derivatives into cyclic alkenyl fluorides by using tetrafluoroboric acid as the proton and fluoride source is reported. This study includes the first biomimetic cationic cyclization/nucleophilic fluorination reaction of polyenyne derivatives to give terpenoid derivatives.