Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry. Protective treatments against these infections have thus far limited efficacy. In this study we generated nanobodies directed against the lectin domain of the F18 fimbrial adhesin FedF and showed in an in vitro adherenc...

It has been reported that F18-fluorodeoxyglucose (FDG) uptake in the neck and supraclavicular lesions represents activated brown adipose tissue (BAT). In the present study, the association between BAT activity, detected by FDG-positron emission tomography (PET), and the clinicopathological features of patients with breast cancer was investigated. The cases of 156 consecutive patients with breas...

Background: Bacteriophages are viruses that infect bacteria and therefore are widespread in nature. Those that lyse the pathogen Salmonella enterica serovar Enteritidis (SE) should be expected in niches in which this bacterium thrives, among others the avian egg. Furthermore, bacteriophages could remain viable in this milieu. Results: Upon artificially infecting hen eggs with the SE bacteriopha...

Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are one of the key components of antiretroviral drug regimens against human immunodeficiency virus type 1 (HIV-1) replication. (+)-calanolide A, which is purified from the rainforest plant Calophyllum, is an anti-HIV-1/ tuberculosis drug. In our previous study, a library of (+)-calanolide A was constructed and one novel compound 10-chloro...

Sato J.P.H., Takeuti K.L., Andrade M.R., Koerich P.K.V., Tagliari V., Bernardi M.L., Cardoso M.R.I. & Barcellos D.E.S.N. 2016. Virulence profiles of enterotoxigenic Escherichia coli isolated from piglets with post-weaning diarrhea and classification according to fecal consistency. Pesquisa Veterinária Brasileira 36(4):253-257. Setor de Suínos, Faculdade de Veterinária, Universidade Federal do R...

Adherence of F18 fimbrial Escherichia coli to porcine intestinal epithelial cells is mediated by the adhesin (FedF) of F18 fimbriae. In a previous study, we demonstrated the specificity of the amino acid residues between 60 and 109 as the receptor binding domain of FedF. In this study, different expression, secretion, and anchoring systems for the receptor binding domain of the FedF adhesin in ...

Apart from the historical and clinical relevance of positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG), various other new tracers are gaining a remarkable place in functional imaging. Their contribution to clinical decision-making is irreplaceable in several disciplines. In this brief review we aimed to describe the main non-FDG PET tracers based on their clinical relevanc...

We serially examined a patient with Creutzfeldt-Jakob disease using fludeoxyglucose F 18 and positron emission tomography. Marked cerebral hypometabolism reflected clinical deterioration in the early stages of Creutzfeldt-Jakob disease when no parenchymal abnormalities were present on MR imaging.

glucose (FDu) has diagnostic value in monitoring the effects of therapy, for example, in oncology (/ ) and in basic research on brain function (2-4). Some applications do not require absolute quantification since relative values of MRglc are sufficient. Quantification is essential, however, for comparisons between repeated measurements (5) or between results from different laboratories. The sta...

Infectious lymph nodes mimicking lymphoma is challenging for accurate staging. Although 18F-FDG is a nonspecific tracer accumulating not only in tumor cells but also in inflammatory tissues, the metabolic features and uptake kinetics give valuable information: 18F-FDG PET/CT appears as a useful problem solver tool in ambiguous situation.