A characterization and optimization of the in vitro transdermal iontophoretic transport of 5-hydroxy-2-(N,N,-di-n-propylamino)tetralin (5-OH-DPAT) is presented. The utility of acetaminophen as a marker of electroosmotic flow was studied as well. The following parameters of iontophoretic transport of 5-OH-DPAT were examined: drug donor concentration, electroosmotic contribution, influence of co-...

In the last decades much effort was put in understanding fouling phenomena on membranes. One successful approach to describe fouling issues on membranes is the critical flux theory. The possibility to measure a maximum value of the permeate flux for a given system without incurring in fouling issues was a breakthrough in membrane process design. However, in many cases critical fluxes were found...

Activation of the alpha7 nicotinic acetylcholine receptor (α7nAchR) is regulated by prion protein (PrPC) expression and has a neuroprotective effect by modulating autophagic flux. In this study, we hypothesized that PrPC may regulate α7nAchR activation and that may prevent prion-related neurodegenerative diseases by regulating autophagic flux. PrP(106-126) treatment decreased α7nAchR expression...

in this paper, a three-dimensional finite element model has been developed to simulate the laser-tig hybrid welding (hlaw) of stainless steel 1.4418 with thickness of 4 mm. transient temperature profile and dimensions of the fusion zone and heat affected zone (haz) during welding process are calculatedusing finite element method (fem) and were solved in the abaqus/standard software.the heat sou...

a bearingless induction machine has combined characteristics of induction motor and magnetic bearings. therefore, the advantages are small size and low-cost. in the magnetic suspension of the bearingless motors, suspension forces are generated based on the feedback signals of displacement sensors detecting the movement of the rotor shaft. the suspension forces are generated taking an advantage ...

numerous investigations have been devoted towards understanding the hydrodynamics of gas jets in fluidized beds. however, most of them address the problem from  macroscopic point of view, which does not reveal the true behavior in the jet region at the single particle level. the present work aims to understand the jet behavior from a more fundamental level, i.e. the individual particle level. a...

some formulations of drug in adhesive transdermal drug delivery systems ()tddss)( with different functional and non-functional acrylic pressure sensitive adhesives psas)( were prepared. for this purpose fentanyl was used as a drug component. the effects of psas type on skin permeation and in vitro drug release from devices were evaluated using hydrodynamically well-characterized chien permeatio...

A Nielsen-Olesen vortex usually sits in an environment that expels the flux that is confined to the vortex, so flux is not present both inside and outside. We construct vortices for which this is not true, where the flux carried by the vortex also permeates the ‘bulk’ far from the vortex. The idea is to mix the vortex’s internal gauge flux with an external flux using off-diagonal kinetic mixing...