Transient elevations in Ca2+ have previously been shown to promote focal adhesion disassembly and cell motility through an unknown mechanism. In this study, evidence is provided to show that CaMK-II, a Ca2+/calmodulin dependent protein kinase, influences fibroblast adhesion and motility. TIRF microscopy reveals a dynamic population of CaMK-II at the cell surface in migrating cells. Inhibition o...

The nuclear transport of paxillin appears to be crucial for paxillin function but the mechanism of transport remains unclear. Here, we show that the nuclear transport of paxillin is regulated by focal adhesion turnover and the presence of FAT domains. Focal adhesion turnover was controlled using triangular or circular fibronectin islands. Circular islands caused higher focal adhesion turnover a...

Intermediate-focus earthquakes are known to show features such as nondouble-couple focal mechanisms that indicate source complexities. To characterize these features, we have systematically studied the low-frequency radiation from 108 intermediate-focus earthquakes recorded by high-performance seismic networks from 1989–1997 whose total moment was 3 10 N m. We determined frequency-dependent foc...

Atrial fibrillation (AF) is the most frequent supraventricular arrhythmia, and its therapy is still unsatisfactory. Different theories have been proposed to explain its mechanism. Nowadays it seems well accepted that both focal and re-entrant mechanisms are involved, playing a different role in the initiation and maintenance of the arrhythmia. Moreover, the importance of each mechanism varies i...

Previously, we reported that phorbol 12-myristate 13-acetate (PMA)-activated protein kinase C (PKC) induced Rac1 activation in A172 glioblastoma cells. In this study, we investigated the mechanism of PMA-activated PKC-induced migration of glioblastoma cells by focusing on Rac1. PMA-induced formation of lamellipodia and focal complexes following migration were blocked by inhibiting Rac1 with sma...

Interaction of integrins with the extracellular matrix leads to transmission of signals, cytoskeletal reorganizations, and changes in cell behavior. While many signaling molecules are known to be activated within Rac-induced focal complexes or Rho-induced focal adhesions, the way in which integrin-mediated adhesion leads to activation of Rac and Rho is not known. In the present study, we identi...

Rasmussen’s encephalitis (RE) is neurological disorder of childhood characterized by uni-hemispheric inflammation, intractable focal epilepsy and progressive cognitive and neurological deficits. Currently, hemispherectomy is the only effective method to control the seizures associated with RE. Although this disease has been heavily investigated, the pathogenesis of RE with unilateral cortex atr...

When an earthquake occurs, seismologists want to use recorded seismograms to infer its location, magnitude and source-focal mechanism as quickly as possible. If such information could be determined immediately, timely evacuations and emergency actions could be undertaken to mitigate earthquake damage. Current advanced methods can report the initial location and magnitude of an earthquake within...

in this paper, we study b-focal curves of biharmonic b -general helices according to bishop frame in the heisenberg group heis   finally, we characterize the b-focal curves of biharmonic b- general helices in terms of bishop frame in the heisenberg group heis

In this paper, we study B-focal curves of biharmonic B -general helices according to Bishop frame in the Heisenberg group Heis   Finally, we characterize the B-focal curves of biharmonic B- general helices in terms of Bishop frame in the Heisenberg group Heis