OBJECTIVE To report the efficacy of FNAC in patients with thyroid disease. METHODS Between January 1990 and December 1994 the records of all patients treated surgically for thyroid disease at ENT Head and Neck Surgery of Aga Khan University were reviewed. All the patients had pre-operative FNAC as the first line of evaluation and the histopathologist examined post-operative thyroid specimen. ...

BACKGROUND Werner syndrome (WS), an autosomal recessive disease characterized by premature aging, has a high frequency of association with six rare neoplasms in Japanese patients, and only four of these neoplasms also occur excessively in whites. Several differ from what is usual in their epidemiology and/or histology. Described in this article are peculiarities in the occurrences of follicular...

K.Y. Lam, FRCPA, Department of Pathology, Queen Mary Hospital, Hong Kong (Hong Kong) Dear Sir, Although secondary tumors involving the kidneys are not uncommon, it is rare to find thyroid carcinoma giving rise to solitary renal metastasis. We describe such a case with atypical features. A 91-year-old Chinese woman presented with acute onset of epigastric pain and vomiting. She also suffered fro...

Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been alr...

hashimoto’s thyroiditis, the most common autoimmune thyroid disease, is due to destruction of the thyroid gland by autoantibodies. various types of thyroid malignancies may arise in hashimoto’s thyroiditis. follicular carcinomas, papillary carcinomas, lymphomas, medullary carcinomas and hurthle cell neoplasms may develop in hashimoto’s thyroiditis. we present a rare case report of a 35-year-old...

OBJECTIVE Thyroid proteomics is a new direction in thyroid cancer research aiming at etiological understanding and biomarker identification for improved diagnosis. METHODS Two-dimensional electrophoresis was applied to cytosolic protein extracts from frozen thyroid samples (ten follicular adenomas, nine follicular carcinomas, ten papillary carcinomas, and ten reference thyroids). Spots with d...

Background: Thyroid cancer is the most frequently occurring of endocrine organs. From past few decades, prevalence thyroid carcinoma increasing generally and this has aroused great public concern.Papillary primarily responsible for high prevalence.The cases other types malignancies have remained stable over time. Aim: To analyze our institution-based trends in histopathological characteristics ...

Tumor-to-tumor metastasis is extremely rare in the thyroid glands, and only seven cases of lung carcinoma metastasizing to thyroid tumors have been reported in the literature. We report another two cases of lung carcinoma metastasizing to thyroid neoplasms and review of the literature. The first case was a 64-year-old man presenting with neck mass, hoarseness, and easy choking for 2 months. Ima...

Several types of thyroid cancer ± classic papillary, anaplastic and medullary thyroid carcinoma ± can be confidently diagnosed and distinguished through fineneedle aspiration cytology (FNAC) of a thyroid nodule, thanks to their characteristic morphology and additional immunocytochemistry. In contrast, the finding of follicular thyroid neoplasia, a cytological group diagnosis encompassing the th...

Primary cilia are found in the apical membrane of thyrocytes, where they may play a role in the maintenance of follicular homeostasis. In this study, we examined the distribution of primary cilia in the human thyroid cancer to address the involvement of abnormal ciliogenesis in different thyroid cancers. We examined 92 human thyroid tissues, including nodular hyperplasia, Hashimoto's thyroiditi...