BACKGROUND Motor-driven transport along microtubules is a primary cellular mechanism for moving and positioning organelles. Many cargoes move bidirectionally by using both minus and plus end-directed motors. How such cargoes undergo controlled net transport is unresolved. RESULTS Using a combination of genetics, molecular biology, and biophysics, we have identified Halo, a novel regulator of ...

Developing and promoting self-directed learning, as an one of the goals in higher education is important because it expected from students to reach the high level of individual capabilities, and able to identify their training needs in order to fix it and evaluate their own learning, without being in a special education system. Conclusion: The literature review showed that self-directed learnin...

the european authors and thinkers in classic period and particularly romantic one were searching the root and basis of european culture and languages. the decoding of sanskrit emphasized the centrality of the orient for european culture. goethe, the famous poet and author of germany, under the influence of this movement and for his own interest, studied the works of orientalists too. alltough h...

One of user's queries from navigation service is to find the nearest facility in terms of time. The facility that is being questioned by the user as a destination may have a queuing service system (e.g. bank), which means that the cost function of the shortest path includes the waiting time at the destination as well as the travel time. This research conducts in the zone 1 of Mashhad with Bank ...

We study two speedup techniques for route planning in road networks: highway hierarchies (HH) and goal directed search using landmarks (ALT). It turns out that there are several interesting synergies. Highway hierarchies yield a way to implement landmark selection more efficiently and to store landmark information more space efficiently than before. ALT gives queries in highway hierarchies an e...

Rooted in the near repeat phenomenon and police crime analysis, a crime “flare up” or micro-time hot spot is the emergence of several closely-related crimes within a few minutes’ travel distance from one another. It occurs within 1–2 weeks and can last several weeks or months before running its course and cooling down. A micro-time hot spot is a type of crime pattern identified by police crime ...