The intension behind the present work was formulation and evaluation of in situ gel of brimonidine tartrate. Brimonidine tartrate is an antiglaucomic agent which shows rapid precorneal exclusion and reduced ocular bioavailability when given in form of conventional ophthalmic formulations. To avoid this, an attempt has been made to formulate thermosensitive in situ gel of brimonidine tartrate to...

Thermogravimetry (TG) and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, formulation compatibility among others. Verapamil hydrochloride shows thermal stability up to 18...

A HPLC method has been described for simultaneous determination of Losartan potassium and Metolazone in formulation. This method is based on a HPLC separation of the two drugs on the Thermo Hypersil BDS-C(18) (250 mm × 4.6 mm, 5.0 μm) with isocratic conditions and a simple mobile phase containing acetonitrile:water (60:40) at a flow rate of 0.8 mL/min using UV detection at 237 nm. This method h...

Serratiopeptidase, an enzyme derived from Serratia marcescences strain E-15 (ATCC 21074), present in the gut wall of the silk worm possesses anti-inflammatory properties, and can prove to be a suitable alternative to commonly used non steroidal antiinflammatory agents. Being sensitive to gastric degradation, serratiopeptidase is conventionally given orally in the form of enteric coated tablet f...

Aim: The aim of this study was to design fast dissolving tablets (FDT) the anti -psychiatric drug, Haloperidol in liquisolid forms as a way enhance its dissolution profile and anti-psychiatric effect.
 Methodology: Solubility studies various solvents surfactants were conducted. solvent with high solubilizing ability tween 20 (80%), selected absorbed into carrier then coating material added...

In the present study an attempt was made to formulate and evaluate Calcium and Vitamin K3 tablet using wet granulation technique incorporating various Excipients like Starch Powder, Starch Paste, Magnesium Sterate, Aerosil, Talc, Lactose, Vitamin K Liquid form and Water. The Formulated tablets were evaluated for different physicochemical properties like rheological properties, weight variation,...

The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioavailability. Chitosan and HTCC-coated lipid particles had higher zeta-potential values than uncoat...

Assessing how excipients affect the self-association of monoclonal antibodies (mAbs) requires informative and direct in situ measurements for highly concentrated solutions, without sample dilution or perturbation. This study explores the application of solution nuclear magnetic resonance (NMR) spectroscopy for characterization of typical mAb behavior in formulations containing arginine glutamat...

It has been estimated that nearly 35-40 % of drugs suffer from poor aqueous solubility and it affects the absorption of drug from gastrointestinal tract that leads to high inter and intra subject variability, poor oral bioavailability, increase in dose, reduction in therapeutic efficiency and finally failure in formulation development. Various formulation strategies like micronization, solubili...

The purpose of the present study was to develop a formulation of recombinant hepatitis B vaccine with improved stability at elevated temperatures. A validated in vitro antigen reactivity assay was used to measure the stability of the vaccine. The formulation development focused on modification of the interactions between the antigen and aluminum hydroxide adjuvant and subsequent optimization of...