Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with wide range of cognitive, behavioral and medical problems. It arises from the silencing fragile mental retardation 1 (FMR1) gene and, consequently, in absence its encoded protein, FMRP (fragile protein). ubiquitously expressed multifunctional RNA-binding primarily considered as translational regulator. Pre-clinical studies...

Two studies were carried out to examine the persistence (Study 1) and characteristics (Study 2) of mathematics learning disability (MLD) in girls with Turner syndrome or fragile X during the primary school years (ages 5-9 years). In Study 1, the rate of MLD for each syndrome group exceeded the rate observed in a grade-matched comparison group, although the likelihood of MLD persisting through t...

David Morales-Alamo, Marcos Martin-Rincon, Mario Perez-Valera, X Samuele Marcora, and José A. L. Calbet Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), Las Palmas de Gran Canaria, Canary Islands, Spain; Department of Sports and Informat...