This study assessed age-related and gender differences in the relative contribution of fragility and crash over-representation to serious injuries per crash-involved driver in Western Australia. Police-reported crashes for the period 1998-2003 were extracted from the Western Australian Road Injury Database. For each passenger vehicle driver age and gender group, serious injuries per crash-invol...

OBJECTIVE(S) Some but not all studies indicate that individuals with HIV infection are at an increased risk of fracture. We systematically reviewed the literature to investigate whether incidence of fracture (both overall and fragility) differs between individuals with and without HIV. DESIGN A systematic review and meta-analysis. METHODS Medline, Scopus and the Cochrane Library databases f...

Fragility curves depict the relationship between a weather variable (wind speed, gust speed, ice accumulation, precipitation rate) and the observed outages for a targeted infrastructure network. This paper describes an empirical study of the county by county distribution of power outages and one minute weather variables during Hurricane Irene with the objective of comparing 1) ‘as built’ fragil...

OBJECTIVE To determine the proportion of patients with fragility fractures who can be expected to have low bone mineral density (BMD) at the time of fracture and to assist FPs in deciding whether to refer patients for BMD testing. DATA SOURCES MEDLINE, EMBASE, and CINAHL were searched from the earliest available dates through September 2009. STUDY SELECTION English-language articles reporti...

Osteoporosis & bone fragility Every second woman and every fifth man aged 50 years or over sustains a fragility fracture (vertebral, hip, wrist or proximal humerus facture) during the rest of their lifetime [1]. Fractures virtually always lead to temporary morbidity, and with age, the likelihood of permanent and more severe comorbidities markedly increases [2]. For example, of those who sustain...

The present study aimed to evaluate the effect of chronic co-exposure to chlorpyrifos (CPF) and deltamethrin (DLT) on erythrocyte osmotic fragility, lipid peroxidation and the ameliorative effect of alpha-lipoic acid (ALA) on erythrocyte fragility. Thirty-six male Wistar rats divided into six groups of six rats each were used for the study. Groups I (S/oil) and II (ALA) were given soya oil (2 m...

BACKGROUND The presence of a fragility fracture is a major risk factor for osteoporosis, and should be an indicator for osteoporosis diagnosis and therapy. However, the extent to which patients who fracture are assessed and treated for osteoporosis is not clear. METHODS We performed a review of the literature to identify the practice patterns in the diagnosis and treatment of osteoporosis in ...

With the increasing life expectancy, osteoporosis is becoming a major worldwide health problem. Osteoporotic fragility fractures affect the quality of life and are associated with premature mortality. The magnitude of the disease may become larger in developing countries, particularly in the Middle East where the prevalence of low bone mass is higher than in Western countries. Besides two small...

FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluorodeoxyuridine (FdU) that affect intracellular thymidylate levels. FRAXA coincides with a >200 CGG*CCG repeat tract in the 5' UTR of the FMR1 gene, and alleles prone to fragility are associated with Fragile X (FX) syndrome, one of the leading genetic causes of intellectual disability. Using siRNA ...

With the increasing life expectancy, osteoporosis is becoming a major worldwide health problem. Osteoporotic fragility fractures affect the quality of life and are associated with premature mortality. The magnitude of the disease may become larger in developing countries, particularly in the Middle East where the prevalence of low bone mass is higher than in Western countries. Besides two small...