the culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mabs) production. the quality by design (qbd) approach defines the assured quality of the final product through the development stage. an important step in qbd is determination of the main quality attributes. during the media optimization, some of the main quality attribute...

prolonged local consumption of anethum graveolens leaves, as an antihyperlipimic and antihypercholesterolemic agent, has been associated in some patients with skin disorders such as darkening and pigmentation mainly in the exposed areas such as face and hands.anethum graveolens belongs to the umbelliferae family which is belived to be rich in photoactive furocoumarins. an oraganic extract of th...

background: the initial step in the diagnostic investigation of male infertility has been traditionally based on the conventional seminal profile. however, there are significant limitations regarding its ability to determine the underlying mechanisms that cause the disorder. sperm dna fragmentation has emerged as a potential causative factor of reproductive failure and its assessment has been s...

Until recently, many of the dozens of quantitative predictions of the ambipolar-diffusion theory of gravitational fragmentation (or core formation) of molecular clouds have been confirmed by observations and, just as importantly, no prediction has been contradicted by any observation. A recent paper, however, claims that measurements of the variation of the mass-to-flux ratio from envelopes to ...

We develop a fully stochastic theory for coagulation and fragmentation in a finite system with a maximum cluster size constraint. The process is modeled using a high-dimensional Master equation for the probabilities of cluster configurations. For certain realizations of total mass and maximum cluster sizes, we are able to find exact analytical results for the expected equilibrium cluster distri...

Understanding the dynamics of biological diversity requires new approaches and integration between different disciplines. The development of a unitary body of knowledge about biodiversity is made difficult by the fragmentation and lack of interoperability between the diverse and often informal and simplistic semantics adopted for data and models. Different representational paradigms require con...

We point out that the fragmentation of a strange quark into nucleons versus antinucleons is not necessarily identical Dp/s(z,Q ) 6= Dp/s(z,Q ), even though the perturbative contributions from gluon splitting and evolution are p ↔ p symmetric. The observation of such asymmetries in the hadronization of strange and other heavy quarks can provide insight into the nonperturbative mechanisms underly...

In the last few years, the modeling of business processes has achieved considerable popularity in organizations and academic research. However, business process modeling is often studied from either a technical or a social perspective, and as a result of this a priori fragmentation, tends to overlook the sociotechnical complexity involved in modeling projects. To overcome this problem, this pap...

The question this paper explores is the extent to which e-commerce may be liberating consumers and merchants from the constraints of space (and time) that have traditionally led to predictable regional patterns of retail location. Is distance dead, have the laws of regional organization dissolved away in the age of Internet shopping? Following a discussion of some figures, trends and definition...