BACKGROUND Late-life depression and physical frailty are supposed to be reciprocally associated, however, longitudinal studies are lacking. OBJECTIVES This study examines whether physical frailty predicts a higher incidence of depression, as well as a less favorable course of depression. METHODS A population-based cohort study of 888 people aged 65 years and over with follow-up measures at ...

The frailty construct has increasingly been adopted in the field of cognitive disorders. The aim of the present study was to measure frailty in a cohort of individuals with mild cognitive impairment (MCI) and to explore whether frailty measures may consent to predict the risk of conversion to dementia. We retrospectively reviewed the clinical charts of outpatients with amnesic MCI (aMCI) consec...

OBJECTIVES A better understanding of the essential components of frailty is important for future developments of management strategies. We aimed to assess the incremental validity of a Comprehensive Model of Frailty (CMF) over Frailty Index (FI) in predicting self-rated health and functional dependency amongst near-centenarians and centenarians. DESIGN Cross-sectional, community-based study. ...

The objective of this study was, by means of simulation, to quantify the effect of ignoring individual heterogeneity in Weibull sire frailty models on parameter estimates and to address the consequences for genetic inferences. Three simulation studies were evaluated, which included 3 levels of individual heterogeneity combined with 4 levels of censoring (0, 25, 50, or 75%). Data were simulated ...

OBJECTIVE To investigate whether polypharmacy is associated with a higher incidence of frailty in a large cohort of North Americans during 8 years of follow-up. DESIGN Longitudinal study, follow-up of 8 years. PARTICIPANTS A total of 4402 individuals at high risk or having knee osteoarthritis free from frailty at baseline. MEASUREMENTS Details regarding medication prescription were captur...

BACKGROUND Age-related deterioration in homeostatic regulatory mechanisms leads to decreased complexity in their output. For example, the degradation of cardiac autonomic control results in loss of complexity in the heart rate signal. Frailty is a state of critically impaired homeostasis that results in heightened vulnerability to stressors. We propose a new measure of heart rate variability (H...