OBJECTIVE To compare the predictive accuracy of the original and recalibrated Framingham risk function on current morbidity from coronary heart disease (CHD) and mortality data from the Swiss population. METHODS Data from the CoLaus study, a cross-sectional, population-based study conducted between 2003 and 2006 on 5,773 participants aged 35-74 without CHD were used to recalibrate the Framing...

BACKGROUND The purpose of this study was to investigate the pattern of distribution of risk factors for stroke and the 10-year probability of stroke by the Framingham risk score in hypertensive patients visiting private clinics vs. tertiary hospitals. METHODS A total of 2,490 hypertensive patients who attended 61 private clinics (1088 patients) and 37 tertiary hospitals (1402 patients) were e...

OBJECTIVE Our aim was to compare 2 Framingham vascular risk scores with a dementia risk score in relation to 10-year cognitive decline in late middle age. METHODS Participants were men and women with mean age of 55.6 years at baseline, from the Whitehall II study, a longitudinal British cohort study. We compared the Framingham general cardiovascular disease risk score and the Framingham strok...

BACKGROUND Endothelial growth factors including angiopoietin-2 (Ang-2), its soluble receptor Tie-2 (sTie-2), and hepatocyte growth factor play important roles in angiogenesis, vascular remodeling, local tumor growth, and metastatic potential of various cancers. Circulating levels of these biomarkers have a heritable component (between 13% and 56%), but the underlying genetic variation influenci...

OBJECTIVE To determine the extent to which the Framingham function predicts the risk of coronary heart disease (CHD) in Aboriginal people. DESIGN AND SETTING Cohort study in an Aboriginal community in the Northern Territory. PARTICIPANTS 687 Aboriginal people aged 20-74 years were followed up from a baseline examination in 1992-1995 through to 31 December 2003. MAIN OUTCOME MEASURE First ...

OBJECTIVE To evaluate the performance of the QRISK2 score for predicting 10-year cardiovascular disease in an independent UK cohort of patients from general practice records and to compare it with the NICE version of the Framingham equation and QRISK1. DESIGN Prospective cohort study to validate a cardiovascular risk score. SETTING 365 practices from United Kingdom contributing to The Healt...

BACKGROUND Despite reports in the literature that both leisure-time physical activity (LTPA) and commuting physical activity (CPA) can promote health benefits, the literature lacks studies comparing the associations of these domains of physical activity with cardiovascular risk scores. OBJECTIVE To investigate the association between LTPA and CPA with different cardiovascular risk scores in t...

M e t h o d s Design: Cohort study to validate and recalibrate a previously derived prediction rule. Setting: 16 centers from 11 provinces in China. Patients: 30 121 patients (age range 35 to 64 y) without CHD comprised the CMCS validation cohort. Exclusion criteria were a clinical history of myocardial infarction (MI) or angina pectoris. The derivation cohort consisted of 5251 white patients (...

BACKGROUND The American Heart Association has established criteria for the evaluation of novel markers of cardiovascular risk. In accordance with these criteria, we assessed the association between a multi-locus genetic risk score (GRS) and incident coronary heart disease (CHD), and evaluated whether this GRS improves the predictive capacity of the Framingham risk function. METHODS AND RESULT...

INTRODUCTION New Zealand (NZ) guidelines recommend treating people for cardiovascular disease (CVD) risk on the basis of five-year absolute risk using a NZ adaptation of the Framingham risk equation. A diabetes-specific Diabetes Cohort Study (DCS) CVD predictive risk model has been developed and validated using NZ Get Checked data. AIM To revalidate the DCS model with an independent cohort of...