AIMS Long-term randomized comparisons of percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in left main coronary (LM) disease and/or three-vessel disease (3VD) patients have been limited. This analysis compares 3-year outcomes in LM and/or 3VD patients treated with CABG or PCI with TAXUS Express stents. METHODS AND RESULTS SYNTAX is an 85-centre randomized cli...

During a 4-year multicenter cooperative study of acquired factor VIII inhibitors in persons with hemophilia A. new inhibitors were detected in 31 of 1 .306 patients who entered the study without an inhibitor or the history of an inhibitor. The incidence of new inhibitors was eight per 1 .000 patient-years of observation. The factor Vlll:C level before inhibitor development was 0.03 U/mi in 29 m...

BACKGROUND Mammalian heart regenerative activity is lost before adulthood but increases after cardiac injury. Cardiac repair mechanisms, which involve both endogenous cardiac stem cells (CSCs) and cardiomyocyte cell-cycle reentry, are inadequate to achieve full recovery after myocardial infarction (MI). Mice deficient in S-nitrosoglutathione reductase (GSNOR(-⁄-)), an enzyme regulating S-nitros...

BACKGROUND Coronary heart disease (CHD) and myocardial infarction (MI) are associated with neighborhood-level socioeconomic status (SES). Statins are important drugs for secondary prevention of MI. However, no study has determined whether neighborhood-level SES is associated with statin medication in MI patients. We aimed to determine whether there is a difference in statin medication rate in M...

We introduce the theory of modulational instability (MI) of electromagnetic waves in fibers with random polarization mode dispersion. Applying a linear stability analysis and stochastic calculus, we show that the MI gain spectrum reads as the maximal eigenvalue of a constant effective matrix. In the limiting cases of small or large fluctuations, we give explicit expressions for the MI gain spec...

BACKGROUND The combination of cardiovascular risk factors known as the metabolic syndrome is receiving increased attention from physicians, but data on the syndrome's association with morbidity are limited. METHODS AND RESULTS Applying National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria, we evaluated 10 357 NHANES III subjects for the 5 component condition...

This paper presents a novel approach for efficient feature extraction using mutual information (MI). In terms of mutual information, the optimal feature extraction is creating a feature set from the data which jointly have the largest dependency on the target class. However, it is not always easy to get an accurate estimation for high-dimensional MI. In this paper, we propose an efficient metho...

We study the generalized Whittaker models for G = GSp(2,R) associated with indefinite binary quadratic forms when they arise from two standard representations of G: (i) a generalized principal series representation induced from the non-Siegel maximal parabolic subgroup and (ii) a (limit of) large discrete series representation. We prove the uniqueness of such models with moderate growth propert...

BACKGROUND Recent pharmacodynamic and retrospective clinical analyses have suggested that proton pump inhibitors (PPIs) may modify the antiplatelet effects of clopidogrel bisulfate. METHODS We conducted a retrospective cohort study of persons enrolled in a multistate health insurance plan with commercial and Medicare clients to evaluate adverse clinical outcomes in patients using clopidogrel ...

OBJECTIVES to assess the cardioprotective properties of a blueberry enriched diet (BD). BACKGROUND Reactive oxygen species (ROS) play a major role in ischemia-related myocardial injury. The attempts to use synthetic antioxidants to block the detrimental effects of ROS have produced mixed or negative results precipitating the interest in natural products. Blueberries are readily available prod...