In this paper, we deene the Multilevel Rela-tional (MLR) data model for multilevel relations with element-level labeling. This model builds upon prior work of numerous authors in this area, and integrates ideas from a number of sources. A new data-based semantics is given to the MLR data model which combines ideas from SeaView, belief-based semantics and LDV model, and has the advantages of bot...

A new framework is offered that uses multilevel logistic regression (MLR) to analyze data from ‘visual world’ eyetracking experiments used in psycholinguistic research. The MLR framework overcomes some of the problems using conventional analyses, making it possible to incorporate time as a continuous variable and gaze location as a categorical dependent variable. The multilevel approach minimiz...

OBJECTIVE Multiple linear regression (MLR) and machine learning techniques in pharmacogenetic algorithm-based warfarin dosing have been reported. However, performances of these algorithms in racially diverse group have never been objectively evaluated and compared. In this literature-based study, we compared the performances of eight machine learning techniques with those of MLR in a large, rac...

In this study, artificial neural networks (ANNs) and adaptive neuro-fuzzy inference system (ANFIS) were used to estimate shear stress distribution in streams. The methods were applied to the 145 field data gauged from four different sites on the Sarimsakli and Sosun streams in Turkey. The accuracy of the applied models was compared with the multiple-linear regression (MLR). The results showed t...

objective(s): the structure- activity relationship of a series of 36 molecules, showing l-type calcium channel blocking was studied using a qsar (quantitative structure–activity relationship) method. materials and methods: structures were optimized by the semi-empirical am1 quantum-chemical method which was also used to find structure-calcium channel blocking activity trends. several types of d...

Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains undefined. We have examined the effects of FK-506 and CsA on the cytokine generation of human peripheral blood mononuclear cells (PBMCs) in mixed lymphocyte reaction (MLR) with lipopolysaccharide (L...

In light of the widely accepted view that Ia-restricted L3T4+ T helper cells play a decisive role in controlling the differentiation of Lyt-2+ cells, experiments were designed to examine whether Lyt-2+ cells can respond to antigen in the absence of L3T4+ cells. The results showed that highly purified Lyt-2+ cells gave high primary mixed lymphocyte reactions (MLR) to various class I differences,...

The present studies were designed to investigate the mechanism(s) of the defective T cell proliferative response to various stimuli in patients with B cell chronic lymphocytic leukemia B-CLL. In 14 patients with advanced B-CLL (stage III or IV) we found the T cell response in the autologous (auto) and allogeneic (allo) mixed lymphocyte reaction (MLR) to be 35.7% and 30% of the controls, respect...

INTRODUCTION This study is to evaluate the prognostic and predictive value of metastatic lymph node ratio (MLR) in stage III gastric cancer following radical D2 dissection. METHODS 87 patients who underwent radical resection with D2 lymphadenectomy were retrospectively evaluated. The median age was 60 with a 2:1 ratio of male/female. Of these 87 patients, 83 underwent total gastrectomy, the r...

A biologically based neuromuscular simulator was used to produce short(SLR) and medium-latency reflexes (MLR) observed after a stretch of the SO muscle. As expected, SLR was exclusively mediated by the activity of Ia afferents passing through a monosynaptic pathway. The MLR was generated by a summation of effects from Ia and type-II afferents, though it could be generated without the activity o...