Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation, and survival. An agent that enhances production of BDNF is expected to be useful for the treatment of neurodegenerative diseases. Here we report that galectin-1, a member of the family of beta-galactoside binding proteins, induces astrocyte diffe...

alpha-1,3-Fucosyltransferase V (FucT V) catalyzes the transfer of 1-fucose from the donor sugar guanosine 5'-diphospho-beta-1-fucose (GDP-Fuc) to an acceptor sugar. A secondary isotope effect on the fucosyltransfer reaction with guanosine 5'-diphospho-[1-2H]-beta-1-fucose (GDP-[1-2H]-Fuc) as the substrate was observed and determined to be Dv = 1.32 +/- 0.13 and DV/K = 1.27 +/- 0.07. Competitive...

BACKGROUND Farwa is an Island in Libya receives petrochemical wastes generated from General Company of Chemical Industries (GCCI) since more than 40 years. AIM The present work aimed to determine the concentrations of mercury (Hg(+2)) in fish, marine plants and sediment collected from Farwa lagoon to evaluate effect of industrial wastewater from GCCI on the marine environment. METHODS Hundr...

Article history: Received 28 September 2015 Received in revised form 4 December 2015 Accepted 16 December 2015 Available online 18 December 2015 Editor: W.-D. Schlatter The four-lepton (4 , = e, μ) production cross section is measured in the mass range from 80 to 1000 GeV using 20.3 fb−1 of data in pp collisions at √ s = 8 TeV collected with the ATLAS detector at the LHC. The 4 events are produ...

A membrane-bound phospholipid : steryl glucoside acyltransferase from Solanum melongena leaves was partially purified and its specificity and molecular as well as kinetic properties were defined. Among the steryl glycosides tested (e.g. typical plant steryl glucosides, steryl galactosides and cholesteryl xyloside) the highest activity was found with cholesteryl glucoside, but some structurally ...

The expression of the allelic isovitexin 7-O-glycosylation genes gG (transfer of glucose) and g X (transfer of xylose) was studied in cotyledons, rosette leaves, stem leaves and petals of Silene plants. These studies revealed that gG is expressed in all ontogenetic stages, whereas its allele g X is only expressed in the petals. In the vegetative parts of g X individuals 7-O-xylosylation is repl...

Anomers and epimers α- and β-gluco and -galactosides are expected to behave differently. However, recent results on a series of Guerbet glycosides have indicated similar liquid crystal clearing temperatures for pure β-glucosides and the corresponding α-galactosides. This observation has led to speculation on similarities in the self-assembly interactions between the two systems, attributed to t...

The asc operon of Escherichia coli is one of the cryptic genetic systems for beta-D-galactoside utilization as a carbon source. The ascFB genes for beta-D-galactoside transport and catabolism are repressed by the AscG regulator. After genomic SELEX screening, AscG was found to recognize and bind the consensus palindromic sequence TGAAACC-GGTTTCA. AscG binding was detected at two sites upstream ...

The two major theories of cancer metastasis, the seed and soil hypothesis and the mechanical trapping theory, view tumor cell adhesion to blood vessel endothelia and cancer cell aggregation as corresponding key components of the metastatic process. Here, we demonstrate in vitro, ex vivo, and in vivo that metastatic breast and prostate carcinoma cells form multicellular homotypic aggregates at t...

Aronia melanocarpa (A. melanocarpa) berries are a fruit with a marked antioxidant effect. The objective of this study was to confirm the effect of A. melanocarpa berries extract against scopolamine-induced memory impairment in mice using the Morris water maze and passive avoidance test. Moreover, we determined a possible mechanism of the cognitive-enhancing effect involving AChE activity and BD...