BACKGROUND AND PURPOSE Intravoxel incoherent motion MR imaging can simultaneously measure the diffusion and perfusion characteristics of brain tumors. Our aim was to determine the utility of intravoxel incoherent motion-derived perfusion and diffusion parameters for assessing the treatment response of metastatic brain tumor following gamma knife radiosurgery. MATERIALS AND METHODS Ninety-one ...

Purposeː To evaluate the therapeutic effects of copper reduction on angiogenesis-related factors in patients with glioblastoma multiforme treated by gamma knife radiosurgery. Materials and Methodsː In the present block randomized, placebo-controlled trial, fifty eligible patients with a diagnosis of glioblastoma multiforme who were candidates for gamma knife radiosurgery were randomly assigned ...

INTRODUCTION AND OBJECTIVE The acoustic neuroma is a benign tumour that usually affects the vestibular portion of the vestibulocochlear nerve. It represents 8% of all intracranial tumours and 80% of those arising at the cerebellopontine angle. There are 3 treatment options: microsurgery (the technique of choice), radiosurgery and observation. The objective of the study was to evaluate the resul...

Stereotactic radiosurgery is an emerging treatment option offered to patients with glioblastoma (GB). Radiosurgery is performed as an outpatient procedure and provides a safe and effective non-invasive treatment for focal GB. High-energy beams originating from cobalt sources placed into a helmet-shaped device (Gamma Knife®, Elekta) or generated by a linear accelerator (LINAC), rotating on a gan...

The aim of this study was to re-assess whether the use of a 'one-knife technique' can be considered as safe as the alternative practice of using separate skin and inside knives for elective orthopaedic surgery. A total of 609 knife blades from 203 elective orthopaedic operations, with equal numbers of skin, inside and control blades, were cultured using direct and enrichment media. We found 31 ...

Stereotactic radiosurgery is a technique of external irradiation that utilizes multiple convergent beams to deliver a high single dose of radiation to a small volume. In any stereotactic procedure, a coordinate system associated with a stereotactic frame is used both to reference the 10cation of intracranial structures with radiological studies and to direct intervention, such as biopsy, cranio...

BACKGROUND AND PURPOSE The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods. The purpose of this study was to use proton MR spectroscopy to investigate serial changes in recurrent malignant gliomas after gamma knife radiosurgery to characterize tissue response to high-dose radiat...

Purpose: Vascular Endothelial Growth Factor (VEGF) and interleukin-8 (IL-8) appear important in tumor growth. In this study, we have investigated the effect of copper reduction along with gamma knife radiosurgery on IL-8 and VEGF in patients with recurrent glioblastoma multiforme (GBM). Materials and Methods: In a 3-month randomized clinical trial, patients with recurrent GBM were allocated ran...

The polymer gel-Magnetic Resonance Imaging (MRI) dosimetry technique was employed to evaluate the mechanical and dose delivery accuracy in Leksell gamma knife stereotactic radiosurgery for the treatment of multiple targets. Two different polymer gel dosimeter formulations that have been reported in the literature were prepared in-house. A plan for the treatment of four brain metastases (targets...