It is postulated that IFN-gamma confers susceptibility to immunologically mediated tissue injury. To test this hypothesis, we compared the intensity of accelerated anti-glomerular basement membrane glomerulonephritis between wild-type (IFN-gamma+/+) and IFN-gamma gene knockout (IFN-gamma-/-) mice. This disease model is initiated by binding of heterologous (sheep) anti-glomerular basement membra...

Butyrate, a four-carbon fatty acid, and its two-carbon metabolic product, acetate, are inducers of gamma-globin synthesis. To test whether other short-chain fatty acids share this property, we first examined whether propionic acid, a three-carbon fatty acid that is not catabolized to acetate, induces gamma-globin expression. Sodium propionate increased the frequency of fetal hemoglobin containi...

BACKGROUND Failure of passive transfer of maternal immunity via colostrum can occur in the bovine, and a number of blood tests have been developed to test calves for this failure. It is not clear which test is most suitable for this purpose. The objective was to examine the most commonly used tests for failure of passive transfer and to decide which is most suitable for routine laboratory use. ...

We have shown that phenolic antioxidant tocopherols are oxidized to nonarylating alpha-tocopheryl quinone (alpha-TQ) and arylating gamma- and delta-TQ electrophiles. The arylating quinones stimulate apoptosis and are highly cytotoxic in mammalian cells. Some xenobiotic phenolic antioxidants are mutagens, and it has been suggested that their arylating quinone metabolites are the active agents in...

The effect of toxin-gamma from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age) divided into subgroups of 8 animals each. Toxin-gamma was injected i.v. at doses of 25, 37.5, 50 or 100 micrograms/kg and the effect on gastric emptying was assessed 30 min and 8 h later. A time-course study was also performed by ...

GRB 221009A is a bright Gamma-ray burst (GRB) with isotropic energy being larger than $10^{54} ~{\rm ergs}$. Its fairly low redshift makes it promising candidate for high neutrino detection. However, search this reported by the IceCube collaboration yielded null result. In paper, we utilize upper limit from observation to test different prompt emission models. We find that, at least specific bu...

Nursing students are Occupationally at risk group for tuberculosis. Tuberculosis can either be as Latent tuberculosis (LTBI) or as active tuberculosis infection (TBI). Lack of awareness and not taking appropriate self defence exposes this group to acquire tuberculosis. it is the prime responsibility of governments and the managements of hospitals must take care of the health care workers. There...

this paper consider the   general  forms of $(alpha,beta)$-fuzzyleft ideals (right ideals, bi-ideals, interior ideals) of an orderedsemigroup, where$alpha,betain{in_{gamma},q_{delta},in_{gamma}wedgeq_{delta}, in_{gamma}vee q_{delta}}$ and $alphaneqin_{gamma}wedge q_{delta}$. special attention is paid to$(in_{gamma},ivq)$-left ideals (right ideals, bi-ideals, interiorideals) and some related  pr...

Introduction: Interactions of free radicals from ionizing radiation with DNA can induce DNA damage and lead to mutagenesis and carsinogenesis. With respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation. In the present study,the effects of arbutin were investigated by using the micronucleus test for anti- clastog...

Traditionally, allergic contact dermatitis (ACD) has been associated with the activity of Th1 lymphocytes that secrete interferon gamma. Recent evidence indicates that other cells, e.g. interleukin 5 (IL-5)-secreting Th2 or Tc2 cells may be among the key effectors of ACD. The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activ...