A sensitive gas-liquid chromatographic assay for sobrerol in biological fluids has been developed. The assay procedure involves esterification of both hydroxyl groups of sobrerol with pentafluoropropionic anhydride to form the diester which can be quantitated using gas-liquid chromatography-electron-capture detection. The detection limit of plasma sobrerol under the conditions described is 5 ng...

BACKGROUND The challenge in systematic toxicological analysis using gas chromatography and/or liquid chromatography coupled to mass spectrometry is to identify compounds of interest from background noise. The large amount of spectral information collected in one full-scan MS run demands the use of automated evaluation of recorded data files. We evaluated the applicability of the freeware deconv...

Most of the common organic solvents are excreted into urine as metabolites. A correlation exists for several organic solvents between the amount taken in and the amount of metabolites excreted. Many methods have been developed for the measurement of these urinary metabolites. The methods were classified into three group: colorimetry, gas chromatography and high performance liquid chromatography...

A method is described for accurate and reproducible measurement of squalene in plasma, feces, urine, bile, and tissue that depends on isolation by alumina column chromatography after mild saponification and on measurement by gas-liquid chromatography. Recoveries from all tissues exceeded 80% and from plasma 96%; losses were accurately corrected by appropriate additions of squalene as an overall...

A method is described for the identification of amino acid thiohydantoins by two-dimensional t.l.c. An indirect method for the determination of amino acid thiohydantoins is described which, after hydrolysis, the corresponding amino acids are determined by g.l.c.

Econea®, or 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile, is a new type of environmentally friendly anti-fouling compound used in the immersed coatings of commercial sea going vessels. This paper reports the development of a new analytical method to directly detect the active biocide Econea® in an artificial sea water matrix using liquid chromatography mass spectrome...

This review describes the role of wood extractives, especially fatty and resin acids, in papermaking, as well as the importance of their removal from process waters. One of the main aims is also to illustrate versatile analysis methods for this purpose and highlight recent developments in corresponding applications. Most of the current methods require timeconsuming and laborious sample pretreat...

In a previous communication [l] we reported a procedure for the serum determination of midazolam using gas chromatography (GC) with a nitrogenselective detector. GC with nitrogen-selective detection resulted in a selective procedure for the direct determination of midaxolam with a sensitivity of 50 ng/ml. We present, in this paper, a procedure for the direct determination of midazolam and its m...

We describe a micromethod for determining as little as 0.1 microgram of morphine per liter of human urine. The procedure is about 20-fold more sensitive than are currently used gas-liquid chromatographic methods. It is particularly suitable for use as a confirmatory method for large-scale radioimmunoassay screening tests. The procedure involves extraction of morphine from urine and analysis of ...

The congruence between self reported drug use and urinalysis data among 89 consecutive opioid dependents at their first contact in an outpatient clinic was examined. For this purpose self reports of drug use within preceding 72 hr, laboratory analysis of urine samples by thin layer chromatography (TLC) were carried out for various drugs. The same samples were also confirmed by gas liquid chroma...