Gastrointestinal cancer is one of the leading causes of cancer-related mortality in men and women worldwide. The adult stem cell marker LGR5 (leucine-rich repeat-containing, G protein-coupled receptor 5) is highly expressed in a significant fraction of gastrointestinal tumors of the colon, liver, pancreas, and stomach, relative to normal tissues. LGR5 is located on the cell surface and undergoe...

Gastric gastric cancer is the second most common cancer of the gastrointestinal tract, after colorectal cancer (IARC, Globocan 2012). In many countries, especially in developing countries, diagnoses are still made in the advanced stages. Symptoms of gastric cancer that include dyspepsia, nausea and discomfort are not-specific and resemble common gastrointestinal conditions such as peptic ulcer ...

Background: Gastrointestinal Cancers are one of the most important causes of mortality of patients in the world as well as in our country. The North of Iran is in Asian belt of esophagus cancer in addition, in other areas of our country gastric cancer is the most common GI Cancer. Because GI Cancers are common in Lorestan, we decided to study them in patients undergo endoscopy and colonoscopy i...

The interleukin-18 (IL-18) gene -607 C/A polymorphism has been reported to be associated with gastrointestinal cancer, but there are conflicting results from previous studies on said topic. Therefore, the aim of this meta-analysis is to derive a more precise estimation of the association between the -607 C/A polymorphism in the IL-18 gene and gastrointestinal cancer risk. Literature searches of...

It is well established that cancer arises in chronically inflamed tissue, and this is particularly notable in the gastrointestinal tract. Classic examples include Helicobacter pylori-associated gastric cancer, hepatocellular carcinoma, and inflammatory bowel disease-associated colorectal cancer. There is growing evidence to suggest that this association is not coincidental but may indeed be cau...

Short non-coding RNAs, miRNAs, play roles in the control of cell growth and differentiation cancer. Reportedly, introduction miRNAs could reduce biologically malignant behavior cancer cells, suggesting a possible use as therapeutic reagents. Given that forced expression several including miR-302, results cellular reprograming human mouse which is similar to effects transcription factors Oct4, S...

Pancreatic adenocarcinoma is the most pervasive form of cancer with high mortality rates. Being obscure at early stages, non-specific symptoms and their onset only in late stages disease lead to detection III–IV on initial diagnistics. Gastrointestinal stromal tumor (GIST) an intramucosal gastrointestinal tract, which a derivate interstitial cells Cajal. The unicity presented clinical case rare...

OBJECTIVE To determine the age, sex and relative frequencies of various gastrointestinal malignancies in patients registered with the National Cancer Registry from the Western Region of Saudi Arabia from January 1994 till December 1997, and compare this data with previous hospital based studies about the pattern of these malignancies in Saudi Arabia. METHODS A National Cancer Registry was est...

Gastrointestinal metastases from lung cancer are rare and usually asymptomatic. We report a case of small bowel metastases from primary lung cancer revealed by abdominal pain and severe recurrent anaemia. The diagnosis was obtained with capsule endoscopy. This non-invasive procedure thus represents a valuable method contributing to a rapid and detailed diagnosis while reducing underdiagnosis, a...