mycophenolate mofetil (mmf) as an immunosuppressive agent is used to prevent graft rejection. one of the adverse effects of long time administration of mmf is the gastrointestinal disorder. this study aimed to investigate the gastroprotective effect of silymarin (smn) on mmf-induced gastrointestinal (gi) disorders. twenty-four adult female wistar rats were assigned into three groups including t...

conclusions our results showed that mo extract may have a gastroprotective effect against experimental gastric ulcers in rats. the exact mechanism has not yet been determined, but it may be due to enhancing enzymatic antioxidant defenses and inhibiting lipid peroxidation. materials and methods male wistar rats (200 - 250 g) were starved for 24 hours prior to the induction of gastric ulceration ...

Mycophenolate mofetil (MMF) as an immunosuppressive agent is used to prevent graft rejection. One of the adverse effects of long time administration of MMF is the gastrointestinal disorder. This study aimed to investigate the gastroprotective effect of silymarin (SMN) on MMF-induced gastrointestinal (GI) disorders. Twenty-four adult female Wistar rats were assigned into three groups including t...

Helicobacter pylori (H. pylori) successfully colonizes the human stomach of the majority of the human population. This infection always causes chronic gastritis, but may evolve to serious outcomes, such as peptic ulcer, gastric carcinoma or mucosa-associated lymphoid tissue lymphoma. H. pylori first line therapy recommended by the Maastricht-4 Consensus Report comprises the use of two antibioti...

Introduction. Non-steroidal anti-inflammatory drugs (NSAIDs) are ranked first among the world's effective and analgesic with anticipated side effects. That is why prevention of development adverse reactions associated NSAIDs, in particular, those related to their ulcerogenicity, remains a serious global problem. Aims. To characterize mechanisms gastrocytoprotective activity cryopreserved placen...

Ximenia americana L., popularly known in Brazil as “ameixa do-mato, ameixa-brava, and ameixa-do-sertão,” is widely used folk medicine to treat several intestinal disorders. The present study assessed the potential mechanisms of action underlying gastroprotective activity hydroethanolic extract L. (EHXA) stem bark. acute toxicity EHXA was estimated, later, effect mice through models gastric lesi...