BACKGROUND Giant cell tumors (GCTs) of bone are primary benign bone tumors that are characterized by a high number of osteoclast-like multinuclear giant cells (MNCs). Recent studies suggest that the spindle-shaped stromal cells in GCTs are tumor cells, while monocyte-like cells and MNCs are reactive osteoclast precursor cells (OPCs) and osteoclasts (OCs), respectively. In this study, we investi...

Giant cell tumor (GCT) of bone consists of three major cell types: giant cells, monocytic cells, and stromal cells. From microarray analysis, we found that miR-106b was down-regulated in GCT clinical samples and further determined by fluorescence in situ hybridization. In addition, the expression of novel potential target of miR-106b, RANKL, was elevated in GCT along with previously determined ...

Granulosa cell tumor (GCT) is an uncommon malignant neoplasm primarily arises from the sex-cord stromal cells of the ovary. They represent about 5 to 8 % of all cancers of the ovary. They belong to the category of sex-cord stromal tumors: juvenile or adult types are frequently used in the literature. Juvenile GCT represents only 5% of this tumor and usually occurs in pre-pubertal girls and wome...

Owing to striking features of numerous multinucleated cells and bone destruction, giant cell tumor (GCT) of bone, often called as osteoclastoma, has drawn major attractions from orthopaedic surgeons, pathologists, and radiologists. The name GCT or osteoclastoma gives a false impression of a tumor comprising of proliferating osteoclasts or osteoclast precursors. The underlying mechanisms for exc...

INTRODUCTION: Granular Cell tumor(GCT) is an uncommon soft tissue tumor with an incidence of 0.017 – 0.029 % in general surgical specimen 1. They usually occur as solitary tumors, but are multiple in about 10% of the cases 2. Though the most common site of involvement is the tongue 3, it is also found in other sites. Granular cell tumor was originally described in 1926 as granular cell myoblato...

We report a case of Giant Cell Tumor (GCT) arising from anterior are of first rib along with literature review which was treated with excision of rib through its normal margin along with tumor mass. GCT of rib is rare and if found mostly arises from the posterior aspect. However, GCT should be considered as differential diagnosis when bony mass is present in the anterior are of rib. It poses su...

Germinomas and embryonal carcinomas are central nervous system (CNS) germ cell tumors (GCT) that may overexpress the proto-oncogene c-KIT, a receptor tyrosine kinase, of which dasatinib is a potent inhibitor. This retrospective review presents the feasibility and tolerability of dasatinib administration in select patients with CNS germinoma. Between November 2008 and April 2010, six patients wi...

Granular cell tumor (GCT) is an uncommon, usually benign neoplasm; however, a malignant potential has been described. Malignant GCT is an extremely rare neoplasm showing rapid growth and invasion into adjacent muscles, lymph nodes, or vessels, or even distant metastasis. We recently experienced a case of a histologically benign or atypical but clinically malignant GCT, with invasion of the lymp...

BACKGROUND Esophageal granular cell tumor (GCT) is a rare benign tumor with malignant potential. With wide application of endoscopic techniques, the esophageal GCT discovery rate and treatment strategy has changed. This study was to preliminarily evaluate outcomes of endoscopic diagnosis and treatment for esophageal GCT. METHODS Fourteen patients (eight men, six women; median age, 48.5 years)...

In this paper, we propose a graph correspondence transfer (GCT) approach for person re-identification. Unlike existing methods, the GCT model formulates person re-identification as an off-line graph matching and on-line correspondence transferring problem. In specific, during training, the GCT model aims to learn off-line a set of correspondence templates from positive training pairs with vario...